KSR1 and ITCH

  • Number of citations of the paper that reports this interaction (PubMedID 31015455)
  • 8
  • Data Source:
  • BioGRID (enzymatic study)

KSR1

ITCH

Description kinase suppressor of ras 1 itchy E3 ubiquitin protein ligase
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007)
  • Crohn's disease ( 28067908)
  • Monocyte count ( 32888494 27863252)
  • Monocyte percentage of white cells ( 32888494 27863252)
  • Systemic lupus erythematosus ( 28714469)
Interacting Genes 10 interacting genes: BRAP EPHB2 ITCH MAP2K1 MAPK1 MARK3 NME1 PJA2 RAF1 YWHAZ 108 interacting genes: AGO2 ARHGEF7 ARID1A ARRB2 ARRDC3 ATN1 BECN1 BIN1 BRAF CBL CBLC CDC34 CEP250 CPSF6 CPSF7 CSNK2A1 CXCR4 CYLD DAZAP1 DTX1 DTX3L ERBB4 EWSR1 FYN GLIS3 GNAI2 HNRNPL HNRNPUL1 JUN JUNB KPNB1 KSR1 LAPTM5 LITAF LRRK1 MAP2K1 MAP2K4 MAPK8 MLANA N4BP1 NDFIP1 NDFIP2 NEDD9 NFE2 NOTCH1 NRAS NUDT21 NUMB PABPC1 PACSIN1 POLR2A POLR2B POLR2C POLR2E POU5F1 PRKACA PRRG4 RAF1 RIPK1 RNF11 RPAP2 RPAP3 SCNN1A SCNN1B SF1 SGK3 SH3GL1 SH3GL2 SMAD2 SMAD3 SMARCC1 SMARCC2 SMARCE1 SMN1 SNX9 SPART STAM2 SUFU TAB1 TP63 TP73 TRPC4 TRPV1 TRPV4 UBAP2 UBAP2L UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2J2 UBE2K UBE2L3 UBE2M UBE2O UBE2Q1 UBE2Q2 UBE2R2 URI1 WASL WBP2 YWHAQ
Entrez ID 8844 83737
HPRD ID 18980 07565
Ensembl ID ENSG00000141068 ENSG00000078747
Uniprot IDs Q8IVT5 A0A590UJQ1 Q96J02
PDB IDs 5VYK 7JUW 7JUX 7JUY 7JUZ 7JV0 7JV1 2DMV 2KYK 2NQ3 2P4R 2YSF 3TUG 4ROF 5C7M 5CQ2 5DWS 5DZD 5SXP
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?