IL1RL2 and IL18

Number of citations of the paper that reports this interaction (PubMedID 9325300)
86

Data Source:
HPRD (in vivo, in vitro)

		IL1RL2	IL18
Description		interleukin 1 receptor like 2	interleukin 18
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Cytosol
	Molecular Function	Interleukin-1 Receptor Activity Interleukin-1, Type I, Activating Receptor Activity NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating	Cytokine Activity Protein Binding Interleukin-18 Receptor Binding
	Biological Process	Inflammatory Response Cellular Defense Response Signal Transduction Positive Regulation Of Interleukin-6 Production Innate Immune Response Positive Regulation Of T Cell Differentiation Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway	MAPK Cascade Angiogenesis Inflammatory Response Cell-cell Signaling Cell Population Proliferation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Natural Killer Cell Activation Regulation Of Cell Adhesion Sleep Lipopolysaccharide-mediated Signaling Pathway Activation Of Protein Kinase B Activity Positive Regulation Of Chemokine Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Tissue Remodeling Interleukin-18-mediated Signaling Pathway T-helper 1 Type Immune Response Type 2 Immune Response Positive Regulation Of Activated T Cell Proliferation Neutrophil Activation Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Cholesterol Homeostasis Positive Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of NK T Cell Proliferation Positive Regulation Of Protein Kinase B Signaling Triglyceride Homeostasis Cellular Response To Organic Cyclic Compound Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Neuroinflammatory Response Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of T-helper 1 Cell Cytokine Production
Pathways		Interleukin-38 signaling Interleukin-36 pathway	Interleukin-1 processing Pyroptosis Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling Purinergic signaling in leishmaniasis infection
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Asthma ( 31959851 30929738 27182965 31619474 29273806) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738 29273806) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood protein levels ( 30072576 29875488 28240269) Celiac disease ( 20190752) Crohn's disease ( 28067908) Familial squamous cell lung carcinoma ( 29924316) Inflammatory bowel disease ( 28067908 23128233) Primary biliary cholangitis ( 26394269) Self-reported allergy ( 23817569) Serum protein levels (sST2) ( 23999434) Waist circumference ( 23966867)	Blood protein levels in cardiovascular risk ( 28369058) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 27989323 31584380) Protein quantitative trait loci ( 18464913)
Interacting Genes		4 interacting genes: IL18 OTUB1 STAMBP USP2	9 interacting genes: ADIRF CASK CASP1 CASP3 CASP4 IL18BP IL18R1 IL18RAP IL1RL2
Entrez ID		8808	3606
HPRD ID		05150	02976
Ensembl ID		ENSG00000115598	ENSG00000150782
Uniprot IDs		Q9HB29	A0A024R3E0 Q14116
PDB IDs		6U6U	1J0S 2VXT 3F62 3WO2 3WO3 3WO4 4EEE 4EKX 4HJJ 4R6U 4XFS 4XFT 4XFU
Enriched GO Terms of Interacting Partners?
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