EED and EZH1

Number of citations of the paper that reports this interaction (PubMedID 9584197)
38

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		EED	EZH1
Description		embryonic ectoderm development	enhancer of zeste 1 polycomb repressive complex 2 subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol ESC/E(Z) Complex	Chromosome, Telomeric Region Nucleoplasm ESC/E(Z) Complex
	Molecular Function	Transcription Corepressor Binding Protein Binding Enzyme Activator Activity Nucleosome Binding Histone Methyltransferase Activity Identical Protein Binding Histone Methyltransferase Activity (H3-K27 Specific)	DNA Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Histone-lysine N-methyltransferase Activity Nucleosomal Histone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Spinal Cord Development Negative Regulation Of Transcription, DNA-templated Regulation Of Catalytic Activity Histone H3-K27 Methylation	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Anatomical Structure Morphogenesis Hippocampus Development Heterochromatin Assembly Positive Regulation Of Transcription By RNA Polymerase II Histone H3-K27 Methylation
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis
Drugs			Tazemetostat
Diseases
GWAS		Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)	Body shape index ( 34021172) Height ( 31562340) Waist-hip index ( 34021172)
Interacting Genes		42 interacting genes: AEBP2 ANXA5 AR BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FHL1 H1-1 H3C1 HDAC1 HDAC2 HDAC3 ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PJA1 PPP1CA PPP1R8 PRDM14 RACK1 RPS10 SELENBP1 SMYD3 SRPK2 TGS1 TRIM55 TRIM63 TSC22D1 UBE2W YY1 ZBED8 ZFP42	3 interacting genes: E2F6 EED ZMYND11
Entrez ID		8726	2145
HPRD ID		09343	03397
Ensembl ID		ENSG00000074266	ENSG00000108799
Uniprot IDs		E9PJK2 O75530	A0A0A0MSY9 Q92800
PDB IDs		3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27 4W2R 4X3E 5GSA 5H13 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5K0M 5LS6 5TTW 5U5H 5U5K 5U5T 5U62 5U69 5U6D 5U8A 5U8F 5WG6 5WP3 5WUK 6B3W 6C23 6C24 6SFB 6SFC 6U4Y 6W7F 6W7G 6WKR 7KSO 7KSR 7KTP 7KXT	7KSO 7KSR 7KTP
Enriched GO Terms of Interacting Partners?
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