EDF1 and NR5A2

Number of citations of the paper that reports this interaction (PubMedID 12040021)
27

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		EDF1	NR5A2
Description		endothelial differentiation related factor 1	nuclear receptor subfamily 5 group A member 2
Image
GO Annotations	Cellular Component	Intracellular Anatomical Structure Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	TFIID-class Transcription Factor Complex Binding DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Calmodulin Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Multicellular Organism Development Regulation Of Lipid Metabolic Process Positive Regulation Of DNA Binding Endothelial Cell Differentiation Positive Regulation Of Transcription, DNA-templated	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Bile Acid Metabolic Process Hormone-mediated Signaling Pathway Embryo Development Ending In Birth Or Egg Hatching Tissue Development Intracellular Receptor Signaling Pathway Epithelial Cell Differentiation Regulation Of Cell Population Proliferation Homeostatic Process Cholesterol Homeostasis Positive Regulation Of Viral Genome Replication Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Pancreas Morphogenesis Calcineurin-mediated Signaling Cellular Response To Leukemia Inhibitory Factor
Pathways			Estrogen-dependent gene expression
Drugs
Diseases
GWAS			Age at voice drop ( 27182965) Cerebrospinal T-tau levels ( 28247064) Cervical high-risk human papilloma virus infection (persistent) ( 33225922) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) FEV1 ( 30804560) Gamma glutamyl transferase levels ( 29403010 33339817) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hepcidin/transferrin saturation ratio ( 27846281) Hyperinsulinemia in obesity ( 30327367) Hyperinsulinemia x BMI interaction ( 30327367) Inflammatory bowel disease ( 28067908) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Length of menstrual cycle ( 30202859) Lung adenocarcinoma ( 28604730) Lung function (FVC) ( 30061609 30804560) Menarche (age at onset) ( 25231870) Myopia ( 27182965) Nicotine dependence ( 28440896) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Pancreatic cancer ( 29422604 20101243 27579533 26098869 25086665) Refractive error ( 32231278) Rheumatoid arthritis ( 25014791) Ulcerative colitis ( 28067908) Uric acid levels ( 21294900) Urinary albumin excretion ( 30220432)
Interacting Genes		22 interacting genes: ATF1 ATF2 CALM1 CALM2 CALM3 CDC42 CEBPA CREB1 JUN MAPK6 MEOX2 NR1H3 NR5A1 NR5A2 NRL PPARG PRKCA RXRA SOX4 TAF1 TBP UBE2I	21 interacting genes: ALB BCKDK DDB2 EDF1 FTH1 GTF2H2C NCOA1 NCOA3 NPPA NR0B2 NR1I2 NRIP1 NSD1 PNRC1 PNRC2 POLR2D PROX1 RAD54L2 SMARCD3 SREBF1 UBE2I
Entrez ID		8721	2494
HPRD ID		09235	06830
Ensembl ID		ENSG00000107223	ENSG00000116833
Uniprot IDs		O60869	F1D8R9 O00482
PDB IDs		1X57 6ZVH	1YOK 1YUC 1ZDU 2A66 3PLZ 3TX7 4DOR 4DOS 4IS8 4ONI 4PLD 4PLE 4RWV 5L0M 5L11 5SYZ 5UNJ 6OQX 6OQY 6OR1 6VC2 6VIF
Enriched GO Terms of Interacting Partners?
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