SERPINB7 and HRH4

		SERPINB7	HRH4
Description		serpin family B member 7	histamine receptor H4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity
	Biological Process	Negative Regulation Of Endopeptidase Activity Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Platelet-derived Growth Factor Production	Inflammatory Response G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Biological_process Regulation Of MAPK Cascade G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways			Histamine receptors G alpha (i) signalling events
Drugs			Amitriptyline Clozapine Loxapine Chlorpromazine Amoxapine Doxepin Aripiprazole Pheniramine REV131 Histamine Mianserin
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Asthma ( 31361310 30929738 34103634 32296059 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Food allergy ( 29051540) Hen's egg allergy ( 29051540) Systolic blood pressure ( 29208002)	Adult body size ( 32376654) Chronotype ( 30696823) Diastolic blood pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Lung cancer ( 34062886) Response to taxane treatment (docetaxel) ( 23006423)
Interacting Genes		10 interacting genes: FBXO22 HRH4 OGDH PHLPP1 PIGN RELCH RNF152 SLC5A2 TAX1BP1 ZCCHC2	6 interacting genes: ALMS1 CCL16 GNA15 GNAI1 GNAO1 SERPINB7
Entrez ID		8710	59340
HPRD ID		04524	06004
Ensembl ID		ENSG00000166396	ENSG00000134489
Uniprot IDs		A8K3Q8 O75635	B2KJ49 Q9H3N8
PDB IDs
Enriched GO Terms of Interacting Partners?
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