EIF3A and BZW2

Number of citations of the paper that reports this interaction (PubMedID 21745818)
21

Data Source:
BioGRID (pull down)

		EIF3A	BZW2
Description		eukaryotic translation initiation factor 3 subunit A	basic leucine zipper and W2 domains 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Microtubule Postsynaptic Density Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Multi-eIF Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Cytoplasm Membrane
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Structural Molecule Activity Protein Binding Receptor Tyrosine Kinase Binding	Protein Binding Cadherin Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Translation Reinitiation Translational Initiation Negative Regulation Of ERK1 And ERK2 Cascade IRES-dependent Viral Translational Initiation Viral Translational Termination-reinitiation	Nervous System Development Cell Differentiation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Keratoconus ( 33649486) Plateletcrit ( 32888494)	Alzheimer's disease (cognitive decline) ( 23535033) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494 27863252) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
Interacting Genes		24 interacting genes: BBS1 BBS4 BZW2 CACNA1A EIF3B EIF3G EIF3I EIF3J EIF4B EIF4G1 EIF4G2 FXR1 LAMTOR5 LINC01554 MTNR1B PAIP1 REL RNF139 SRPK2 TFIP11 TSC1 UBC UPF1 YWHAZ	9 interacting genes: AGMO AGR3 CDC42 EIF2A EIF2B1 EIF3A GSK3B LINC01554 OGT
Entrez ID		8661	28969
HPRD ID		03618	16571
Ensembl ID		ENSG00000107581	ENSG00000136261
Uniprot IDs		Q14152	A0A024RA42 Q9Y6E2
PDB IDs		3J8B 3J8C 6YBD 6YBT 6ZMW 6ZON 6ZP4 6ZVJ 7A09
Enriched GO Terms of Interacting Partners?
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