NCOA1 and ESR2

Number of citations of the paper that reports this interaction (PubMedID 10809226)
8

Data Source:
HPRD (in vivo)

		NCOA1	ESR2
Description		nuclear receptor coactivator 1	estrogen receptor 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Plasma Membrane Protein-containing Complex Neuron Projection	Chromatin Nucleus Nucleoplasm Mitochondrion
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Nuclear Receptor Binding Aryl Hydrocarbon Receptor Binding Enzyme Binding Estrogen Receptor Binding Nuclear Receptor Coactivator Activity Progesterone Receptor Binding Protein-containing Complex Binding Retinoid X Receptor Binding Protein Dimerization Activity Protein N-terminus Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Steroid Hormone Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Enzyme Binding Estrogen Receptor Activity Estrogen Response Element Binding Receptor Antagonist Activity
	Biological Process	Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose Regulation Of Thyroid Hormone Mediated Signaling Pathway Lactation Male Gonad Development Cerebellum Development Hippocampus Development Hypothalamus Development Cerebral Cortex Development Response To Estradiol Response To Retinoic Acid Response To Progesterone Cellular Response To Hormone Stimulus Positive Regulation Of Apoptotic Process Histone H4 Acetylation Estrous Cycle Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Female Receptivity Positive Regulation Of Transcription By RNA Polymerase II Male Mating Behavior Labyrinthine Layer Morphogenesis Cellular Response To Thyroglobulin Triiodothyronine Regulation Of Cellular Response To Drug	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Growth Intracellular Steroid Hormone Receptor Signaling Pathway Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of DNA-binding Transcription Factor Activity Cellular Response To Estradiol Stimulus Negative Regulation Of Signaling Receptor Activity
Pathways		RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression PPARA activates gene expression Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) HATs acetylate histones Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Circadian Clock Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis Cytoprotection by HMOX1 Heme signaling	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Nuclear Receptor transcription pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ESR-mediated signaling Extra-nuclear estrogen signaling
Drugs		Genistein Corticosterone Prinaberel ERB-196 (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL TO-901317 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE GW-590735 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol 3,20-Pregnanedione Indeglitazar (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid Myristic acid 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z) Aleglitazar	Diethylstilbestrol Conjugated estrogens Progesterone Raloxifene Estrone Tamoxifen Estradiol Trilostane Estramustine Oxybenzone Genistein Prasterone Benzophenone Phthalic Acid Pyrazole Para-Mercury-Benzenesulfonic Acid Naringenin ICI-164384 5-Alpha-Androstane-3-Beta,17beta-Diol 4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)Phenol Quercetin Afimoxifene Estriol Estrone sulfate MF101 CHF 4227 TAS-108 Lasofoxifene Arzoxifene Bazedoxifene Prinaberel ERB-196 [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE 4-(6-HYDROXY-BENZO[D]ISOXAZOL-3-YL)BENZENE-1,3-DIOL 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL (3aS,4R,9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL 17alpha-Estriol (9aS)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one Erteberel (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL Eugenol Octocrylene Enzacamene Equol 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenol Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate Estriol tripropionate Fluoroestradiol F-18
Diseases
GWAS		Asthma ( 29273806) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Breast cancer ( 29058716) Breast Cancer in BRCA1 mutation carriers ( 29058716) Chromium levels ( 26025379) Cognitive function ( 28093568) Diffuse large B cell lymphoma ( 25261932) Hand grip strength ( 29691431) Hip circumference adjusted for BMI ( 34021172) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Atrial fibrillation ( 30061737) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 29700475) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Metabolite levels ( 23823483) Prostate cancer ( 26443449) Red blood cell count ( 32888494 27863252)
Interacting Genes		90 interacting genes: AHR ANKRD11 AR ARID1A ARNT BCL3 CARM1 CCND1 CHMP2A CIITA COPS5 CPS1 CREBBP CXADR CYB561 DDX17 DDX5 EP300 ESR1 ESR2 ESRRA ESRRG FOS FOXA2 FOXO1 GTF2B HADHA HIF1A HNF1A HNF4A HNF4G JUN KANK2 KAT2B MAPK1 NCOR1 NFKB1 NKX2-1 NR1H2 NR1H3 NR1H4 NR1I2 NR1I3 NR2F1 NR2F6 NR3C1 NR3C2 NR4A1 NR5A1 NR5A2 NR6A1 PAGR1 PGR PPARA PPARD PPARG PPARGC1A PPM1B PPP1CB PRMT1 PRMT2 PSMB9 RARA RARB RARG RORA RORB RXRA RXRB SLC28A2 SMARCC1 SMARCE1 SNW1 SRD5A2 SRF STAT3 STAT6 SUMO1 TBP TEAD1 TEAD2 THRA THRB TP53 TRIM27 TRIP4 VDR YWHAH YWHAQ ZNF512	106 interacting genes: AGR3 AKAP13 AKT1 ARID5A BCAS2 CALM1 CALM2 CALM3 CASC3 CASZ1 CCNC CDK8 CYSRT1 DAP3 DDX54 DKK3 DNMT3L DNTTIP2 EP300 ESR1 HOXA1 IL13RA2 IL24 ITIH5 JMJD1C KAT5 KLK9 KPNA3 KPRP KRTAP6-2 LCK LRATD2 MAD2L1 MAPK1 MAPK11 MED1 MED10 MED12 MED14 MED16 MED17 MED20 MED21 MED23 MED24 MED6 MED7 MEOX2 MKNK2 MMS19 MRC2 MSH2 NCOA1 NCOA2 NCOA3 NCOA6 NCOA7 NCOR1 NCOR2 NFKBIB NFKBID NOTCH2NLA NR0B1 NR0B2 NRIP1 OXT PELP1 PIAS1 PIAS2 PIAS3 PLSCR1 PNRC1 PNRC2 PPARGC1A PPP5C PRMT2 PRSS50 PSMC3IP PSMC5 RBFOX2 RBM39 REXO4 RFX6 SERPINH1 SGPP1 SMAD2 SMAD3 SMAD4 SMARCE1 SP1 SRA1 SRC SREBF1 STAT5A SYNE2 TFF1 TRAM1 TRIM24 TRIM59 TRIP4 TXNRD1 WIPI1 YWHAH YWHAQ ZBTB17 ZNHIT3
Entrez ID		8648	2100
HPRD ID		04070	03390
Ensembl ID		ENSG00000084676	ENSG00000140009
Uniprot IDs		Q15788	A0A348FV93 F1D8N3 Q0PTK2 Q7LCB3 Q92731
PDB IDs		1FM6 1FM9 1K4W 1K74 1K7L 1KV6 1N4H 1NQ7 1NRL 1P8D 1PZL 1RDT 1TFC 1U3R 1U3S 1X76 1X78 1X7B 1X7J 1XIU 1XV9 1XVP 1YY4 1YYE 1ZAF 2A3I 2C52 2FVJ 2GTK 2HBH 2HC4 2HCD 2HFP 2NPA 2NV7 2P54 2PRG 3BEJ 3BQD 3CTB 3CWD 3DCT 3DCU 3DR1 3ET1 3ET3 3FEI 3FEJ 3FUR 3FXV 3G8I 3G9E 3GYT 3GYU 3H0A 3HC5 3HC6 3HVL 3IPQ 3IPS 3IPU 3KMR 3LMP 3OKH 3OKI 3OLF 3OLL 3OLS 3OMK 3OMM 3OMO 3OMP 3OMQ 3OOF 3OOK 3P88 3P89 3QT0 3RUT 3RUU 3RVF 3S9S 3T03 3UU7 3UUA 3UUD 3V9Y 3VN2 4DK7 4DK8 4DM6 4DM8 4DQM 4F9M 4FGY 4G1D 4G1Y 4G1Z 4G20 4G21 4G2H 4HEE 4J5X 4JYG 4JYH 4JYI 4MG5 4MG6 4MG7 4MG8 4MG9 4MGA 4MGB 4MGC 4MGD 4RUJ 4RUP 4TUZ 4TV1 4UDA 4UDB 4Y29 5A86 5AVI 5AVL 5AZT 5DSH 5DV3 5DV6 5DV8 5DVC 5DWL 5E7V 5GTN 5GTO 5GTP 5HJS 5JI0 5JMM 5L7E 5L7G 5L7H 5MWP 5MWY 5MX7 5NKY 5NMA 5NMB 5NWM 5OW7 5OW9 5OWD 5Q0J 5Q0K 5Q0L 5Q0M 5Q0N 5Q0O 5Q0P 5Q0Q 5Q0R 5Q0S 5Q0T 5Q0U 5Q0V 5Q0W 5Q0X 5Q0Y 5Q0Z 5Q10 5Q11 5Q12 5Q13 5Q14 5Q15 5Q16 5Q18 5Q19 5Q1A 5Q1B 5Q1C 5Q1D 5Q1E 5Q1F 5Q1G 5Q1H 5Q1I 5X0R 5X8U 5X8W 5Y44 5YCN 5YCP 5YP6 6A5W 6A5X 6A5Y 6A5Z 6A60 6BNS 6E3G 6FO7 6FO8 6FO9 6FOB 6FOD 6GEV 6GG8 6HTY 6ICJ 6IJR 6IJS 6ILQ 6ITM 6JNR 6JQ7 6KTM 6KTN 6L96 6NX1 6P9F 6SSQ 6T2M 6TFI 6U25 6W9H 6W9I 6XP9 7BPY 7BPZ 7BQ0 7BQ1 7BQ2 7BQ3 7BQ4 7JYM 7KXD 7KXE 7KXF	1L2J 1NDE 1QKM 1U3Q 1U3R 1U3S 1U9E 1X76 1X78 1X7B 1X7J 1YY4 1YYE 1ZAF 2FSZ 2GIU 2I0G 2JJ3 2NV7 2QTU 2YJD 2YLY 2Z4B 3OLL 3OLS 3OMO 3OMP 3OMQ 4J24 4J26 4ZI1 5TOA
Enriched GO Terms of Interacting Partners?
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