RUNX3 and GLI1

Number of citations of the paper that reports this interaction (PubMedID 31278361)
7

Data Source:
BioGRID (pull down, affinity chromatography technology)

		RUNX3	GLI1
Description		RUNX family transcription factor 3	GLI family zinc finger 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Core-binding Factor Complex Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Cytosol Axoneme Ciliary Tip Ciliary Base
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding ATP Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Microtubule Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Chondrocyte Differentiation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Hemopoiesis Neuron Differentiation Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Peripheral Nervous System Neuron Development Negative Regulation Of Epithelial Cell Proliferation Response To Transforming Growth Factor Beta	Osteoblast Differentiation Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Spermatogenesis Ventral Midline Development Positive Regulation Of Cell Population Proliferation Regulation Of Smoothened Signaling Pathway Response To Wounding Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Pituitary Gland Development Lung Development Prostate Gland Development Regulation Of Osteoblast Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Morphogenesis Notochord Regression Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Liver Regeneration Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Hepatocyte Proliferation
Pathways		Binding of TCF/LEF:CTNNB1 to target gene promoters RUNX3 regulates CDKN1A transcription RUNX3 regulates NOTCH signaling Regulation of RUNX3 expression and activity RUNX3 Regulates Immune Response and Cell Migration RUNX3 Regulates Immune Response and Cell Migration RUNX3 regulates WNT signaling RUNX3 regulates YAP1-mediated transcription RUNX3 regulates RUNX1-mediated transcription RUNX3 regulates p14-ARF RUNX3 regulates BCL2L11 (BIM) transcription	Degradation of GLI1 by the proteasome Degradation of GLI1 by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Ankylosing spondylitis ( 23749187 21743469) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 32296059 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Celiac disease ( 22057235 20190752) Crohn's disease ( 23266558) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) IgA levels ( 28628107) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lead levels ( 26025379) Lymphocyte counts ( 32888494) Male-pattern baldness ( 29146897 27182965 28196072) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244) Non-albumin protein levels ( 29403010) Psoriasis ( 23143594) Psoriasis vulgaris ( 26626624) Response to protease inhibitor treatment in hepatitis c (peak serum total bilirubin levels) ( 24503447) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Type 1 diabetes ( 34012112)
Interacting Genes		19 interacting genes: CBFB EP300 GLI1 GUCD1 HDAC1 HDAC2 HDAC4 HDAC5 HPCA MYCN NOTCH1 SMAD3 SMURF1 SMURF2 SP110 TLE1 TNFRSF8 TP53 YAP1	23 interacting genes: AQP1 CATSPER1 CCT2 CRYBA4 DYRK1A FEM1B GCC1 IKBKB PRKAA2 PRKACA PRMT1 PRMT5 RAI1 RUNX3 STK36 SUFU TAF9 TRIM42 USP48 WDR77 XBP1 ZIC1 ZIC2
Entrez ID		864	2735
HPRD ID		02565	01311
Ensembl ID		ENSG00000020633	ENSG00000111087
Uniprot IDs		A0A024RAH4 Q13761	B4DNF7 P08151
PDB IDs		5W69	2GLI 4BLB 4KMD 5OM0
Enriched GO Terms of Interacting Partners?
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