MAPKAPK5 and MAPK4

Number of citations of the paper that reports this interaction (PubMedID 18720373)
33

Data Source:
HPRD (in vivo)

		MAPKAPK5	MAPK4
Description		MAPK activated protein kinase 5	mitogen-activated protein kinase 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	P53 Binding Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Regulation Of Translation Signal Transduction Ras Protein Signal Transduction Peptidyl-serine Phosphorylation Negative Regulation Of TOR Signaling Positive Regulation Of Telomere Maintenance Via Telomerase Intracellular Signal Transduction Protein Autophosphorylation Positive Regulation Of Telomerase Activity Cellular Senescence Stress-induced Premature Senescence Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Telomere Capping	MAPK Cascade Protein Phosphorylation Cell Cycle Intracellular Signal Transduction
Pathways		Oxidative Stress Induced Senescence MAPK6/MAPK4 signaling Regulation of TP53 Activity through Phosphorylation	MAPK6/MAPK4 signaling
Drugs		Fostamatinib	Acetylsalicylic acid Minocycline Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 26426971) Coffee consumption ( 29367735) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mean spheric corpuscular volume ( 32888494) Psoriasis ( 28537254) Spleen volume ( 34128465) Tea consumption ( 33080986)	Diastolic blood pressure ( 28135244) Diisocyanate-induced asthma ( 25918132) Granulocyte count ( 27863252) Large HDL particle concentration ( 29084231) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231) Pulse pressure ( 27841878) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 27841878 30578418) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		30 interacting genes: ATF2 CDCA8 EEF2K EIF4E EIF4EBP1 GYS1 HMGB1 HSPB1 HSPB2 JUN LSR MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK4 MAPK6 MAPK9 MBP MYH11 PARK7 PLA2G4A RPL13 SRPK1 SRPK2 TAB1 TP53 ZNF282 ZNF576	6 interacting genes: CALML3 CCND3 CRK GAB1 GAB2 MAPKAPK5
Entrez ID		8550	5596
HPRD ID		09467	01497
Ensembl ID		ENSG00000089022	ENSG00000141639
Uniprot IDs		Q8IW41	B4DEW2 K7ELV1 P31152
PDB IDs
Enriched GO Terms of Interacting Partners?
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