ZCCHC3 and IFIH1

Number of citations of the paper that reports this interaction (PubMedID 30193849)
29

Data Source:
BioGRID (pull down)

		ZCCHC3	IFIH1
Description		zinc finger CCHC-type containing 3	interferon induced with helicase C domain 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Mitochondrion Cytosol
	Molecular Function	Double-stranded DNA Binding RNA Binding Protein Binding Zinc Ion Binding	DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding ATP Binding Zinc Ion Binding ATP Hydrolysis Activity Identical Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Activation Of Innate Immune Response Detection Of Virus Positive Regulation Of Type I Interferon Production Innate Immune Response Defense Response To Virus Cellular Response To Exogenous DsRNA Positive Regulation Of RIG-I Signaling Pathway	Detection Of Virus Response To Virus Protein Sumoylation Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Type III Interferon Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus MDA-5 Signaling Pathway Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Cellular Response To Virus
Pathways			DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321)	Autoimmune thyroid disease ( 32581359) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 33020668) HDL cholesterol levels ( 32203549) Immunoglobulin A ( 20694011) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Psoriasis ( 25903422 20953190 25574825 23143594) Psoriasis vulgaris ( 26626624) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 27399966 26502338 28714469 19838195) Type 1 diabetes ( 21829393 25751624 19430480 17554260 30572963) Vitiligo ( 27723757 22561518) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: IFIH1 OGT	9 interacting genes: APP CCDC50 GPD2 KEAP1 RNF135 TRIM40 TRIM65 USP3 ZCCHC3
Entrez ID		85364	64135
HPRD ID		15701	09507
Ensembl ID		ENSG00000247315	ENSG00000115267
Uniprot IDs		Q9NUD5	Q9BYX4
PDB IDs			2RQB 3B6E 3GA3 4GL2 7JL0 7JL2
Enriched GO Terms of Interacting Partners?
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