PPFIA1 and SHANK2

		PPFIA1	SHANK2
Description		PTPRF interacting protein alpha 1	SH3 and multiple ankyrin repeat domains 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Presynaptic Active Zone	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Cytosol Neurofilament Plasma Membrane Postsynaptic Density Apical Plasma Membrane Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane
	Molecular Function	Protein Binding	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding
	Biological Process	Cell-matrix Adhesion Signal Transduction Synapse Organization Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Protein Localization To Plasma Membrane	Synapse Assembly Learning Positive Regulation Of Cell Population Proliferation Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Long-term Synaptic Potentiation Long-term Synaptic Depression Vocalization Behavior
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Lymphocyte counts ( 32888494)	Bipolar disorder ( 31043756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Hodgkin's lymphoma ( 34216518) Kawasaki disease ( 33692975) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)
Interacting Genes		31 interacting genes: AGTPBP1 CAGE1 CAST CCNH CDK18 CEP70 DTNB DYNC1I2 ELOA ERC1 ERC2 FAM161A GAS8 GIT1 MBIP NCOA2 NDN PPFIA2 PPFIA3 PPFIBP1 PPFIBP2 PPP2R5A PPP2R5D PTPRC PTPRD PTPRF PTPRS SHANK2 TNNT1 TXLNA YWHAG	33 interacting genes: ACE2 ADGRB2 ADGRL1 ADGRL2 ANO1 ARHGAP12 ARHGEF7 BAIAP2 BANF1 CLCF1 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNAJC19 DNM1 DNM2 GMNN HOMER1 MCF2 ORC2 PEX3 PPFIA1 PPP3CA PRSS1 RAB6A RHOT1 RIPOR3 SHARPIN SLC9A3 SSTR2
Entrez ID		8500	22941
HPRD ID		11451	04479
Ensembl ID		ENSG00000131626	ENSG00000162105
Uniprot IDs		B3KVS8 Q13136	A0A590UJ45 A6NHU9 C0SPH0 Q9UPX8
PDB IDs		1N7F
Enriched GO Terms of Interacting Partners?
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