TNS4 and TXK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TNS4	TXK
Description		tensin 4	TXK tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Focal Adhesion	Nucleus Cytoplasm Plasma Membrane
	Molecular Function	Actin Binding Protein Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Apoptotic Process Protein Localization	Positive Regulation Of Cytokine Production Adaptive Immune Response Protein Phosphorylation Activation Of Phospholipase C Activity Integrin-mediated Signaling Pathway Regulation Of Gene Expression Regulation Of Platelet Activation Positive Regulation Of Interferon-gamma Production Peptidyl-tyrosine Autophosphorylation Tissue Regeneration Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Interferon-gamma-mediated Signaling Pathway
Pathways		MET interacts with TNS proteins	FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs			Fostamatinib Zanubrutinib
Diseases
GWAS		Asthma ( 31959851) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042)	Aspartate aminotransferase levels ( 33547301) Crohn's disease ( 23128233) Mean platelet volume ( 32888494) Multiple sclerosis ( 31604244) Platelet distribution width ( 32888494 27863252)
Interacting Genes		27 interacting genes: AR CARD9 CBL CYSRT1 EGFR ERBB3 ERBB4 FKBP10 GAB1 GSTCD HDAC2 HSF2BP KAZN KCTD4 MET NME4 NR3C1 P4HA2 PIH1D1 PIK3R1 PPP3CA RABEP1 RPAIN TRIM21 TRIM27 TXK ZRANB1	40 interacting genes: CBY2 CCDC33 CCR5 CLNK CRK CTLA4 DOK2 DUSP6 EFHC2 EGFR ERBB2 ERBB3 ERBB4 FYN GRB10 GRB2 HOMEZ IKZF1 IKZF4 JRK KIT LCP2 MET NCK2 NELFCD PIK3R1 PRDM14 RBAK SH2D2A SOCS3 SOCS6 SRC STAP2 TEC TNS4 UTP18 YTHDC1 ZNF587 ZNF792 ZNF835
Entrez ID		84951	7294
HPRD ID		12223	02505
Ensembl ID		ENSG00000131746	ENSG00000074966
Uniprot IDs		Q6PJP3 Q8IZW8	P42681
PDB IDs			2DM0
Enriched GO Terms of Interacting Partners?
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