CBX2 and RYBP

Number of citations of the paper that reports this interaction (PubMedID 10369680)
76

Data Source:
HPRD (in vitro, in vivo)

		CBX2	RYBP
Description		chromobox 2	RING1 and YY1 binding protein
Image
GO Annotations	Cellular Component	Euchromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Methylated Histone Binding	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Cell Differentiation Development Of Primary Sexual Characteristics	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Apoptotic Process Multicellular Organism Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Histone H2A Monoubiquitination Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Body size at age 10 ( 32376654) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 28552196 20881960 25282103 25429064 23563607 31562340) Hip circumference adjusted for BMI ( 34021172) Medication use (beta blocking agents) ( 31015401) Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Resting-state electroencephalogram vigilance ( 29703947) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500)
Interacting Genes		22 interacting genes: BOLL CYSRT1 DHX57 H3-4 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP2-4 KRTAP4-12 KRTAP4-4 MDFI MEOX2 RBMY1A1 RBMY1F RBMY1J RBPMS2 RYBP TRIM55 TRIM63	34 interacting genes: ABL1 BANP CASP10 CASP8 CBX2 CRK E2F2 E2F3 E2F4 E2F6 EAF1 FADD FANK1 FHL3 GABPB1 GABPB2 HSPB1 MAPK8IP2 MDM2 NMI NOS1AP PSMB1 PTEN RBBP4 RING1 RNF2 RNF8 SOCS2 UBC UBE3A XAGE1A XAGE1B YY1 ZFP42
Entrez ID		84733	23429
HPRD ID		14397	09607
Ensembl ID		ENSG00000173894	ENSG00000163602
Uniprot IDs		Q14781	Q8N488
PDB IDs		2D9U 3H91 5EPK	3IXS
Enriched GO Terms of Interacting Partners?
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