IL1F10 and IMPDH2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		IL1F10	IMPDH2
Description		interleukin 1 family member 10	inosine monophosphate dehydrogenase 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Extracellular Region Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Protein Binding	Nucleotide Binding DNA Binding RNA Binding IMP Dehydrogenase Activity Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Inflammatory Response To Antigenic Stimulus Inflammatory Response Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide	GMP Biosynthetic Process GTP Biosynthetic Process Circadian Rhythm Lymphocyte Proliferation Retina Development In Camera-type Eye Cellular Response To Interleukin-4
Pathways		Interleukin-38 signaling Interleukin-36 pathway	Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis Potential therapeutics for SARS
Drugs			NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine Selenazole-4-carboxyamide-adenine dinucleotide 6-Chloropurine Riboside, 5'-Monophosphate Inosinic Acid VX-148
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 33547301 34315874) C-reactive protein ( 22939635) C-reactive protein levels ( 33339817 30388399 21300955) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Coronary artery disease ( 29212778) Dysmenorrheic pain ( 27454463) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Inflammatory biomarkers ( 24182552) Interleukin-1-receptor antagonist levels ( 22205395) Interleukin-6 levels ( 33517400) Low density lipoprotein cholesterol levels ( 32154731) Myocardial infarction ( 33532862) Serum alkaline phosphatase levels ( 33547301) Stroke ( 26089329) Total cholesterol levels ( 29083408)	Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		2 interacting genes: IL1R1 IMPDH2	32 interacting genes: AGR2 AKT1 ALS2 AMT APIP APPL1 ATXN2 ATXN7 C1S CEACAM5 CLK1 CPLANE2 DCAF1 DNASE1L3 FBXL7 FXR1 FXR2 IL1F10 KLF7 OGT PIAS4 POU6F2 PRMT1 PXMP2 PXN RAD54L2 RBM15B STAT3 SUMO2 SUMO4 TRAF2 UBQLN4
Entrez ID		84639	3615
HPRD ID		17144	00895
Ensembl ID		ENSG00000136697	ENSG00000178035
Uniprot IDs		Q8WWZ1	A0A384N6C2 P12268
PDB IDs		5BOW	1B3O 1NF7 1NFB 6I0M 6I0O 6U8E 6U8N 6U8R 6U8S 6U9O 6UA2 6UA4 6UA5 6UAJ 6UC2 6UDO 6UDP 6UDQ
Enriched GO Terms of Interacting Partners?
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