TPST1 and CCR1

Number of citations of the paper that reports this interaction (PubMedID 17558413)
25

Data Source:
HPRD (in vitro)

		TPST1	CCR1
Description		tyrosylprotein sulfotransferase 1	C-C motif chemokine receptor 1
Image
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane Integral Component Of Golgi Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Sulfotransferase Activity Protein-tyrosine Sulfotransferase Activity Protein Homodimerization Activity	Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	Peptidyl-tyrosine Sulfation Inflammatory Response 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process	Dendritic Cell Chemotaxis Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis
Pathways		Cytosolic sulfonation of small molecules Gamma carboxylation, hypusine formation and arylsulfatase activation Defective F8 sulfation at Y1699	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Gout ( 22179738)	Arthritis (juvenile idiopathic) ( 33106285) Aspartate aminotransferase levels ( 33547301) Behcet's disease ( 23291587) Celiac disease ( 22057235 20190752 30572963 18311140) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 26192919) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Myocardial infarction ( 33532862) Narcolepsy with cataplexy ( 25986216) Ulcerative colitis ( 26192919 28067908)
Interacting Genes		6 interacting genes: CCR1 CCR8 CMKLR1 CMKLR2 GP1BA SELPLG	43 interacting genes: A4GNT CCL13 CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CD74 CDC25A CREB3 CTNNB1 DAG1 DDX3Y DNAJB12 DUSP7 FAN1 GNA14 GNAI2 GRAMD1A HAS3 JAK1 KRT6A LETMD1 MBP NPM1 PLP2 PRNP PRSS50 PXMP2 QSOX1 STAT1 STAT3 TMEFF1 TMX1 TPST1 TPST2
Entrez ID		8460	1230
HPRD ID		07216	03101
Ensembl ID		ENSG00000169902	ENSG00000163823
Uniprot IDs		A0A024RDK9 O60507	P32246 Q5U003
PDB IDs		5WRI 5WRJ	1Y5D
Enriched GO Terms of Interacting Partners?
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