MED10 and KDM4B

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		MED10	KDM4B
Description		mediator complex subunit 10	lysine demethylase 4B
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Chromatin Nucleoplasm Mediator Complex	Nucleus Nucleoplasm
	Molecular Function	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity	Histone Demethylase Activity Histone H3-methyl-lysine-9 Demethylase Activity Metal Ion Binding Histone H3-methyl-lysine-36 Demethylase Activity
	Biological Process	Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II	Chromatin Remodeling Histone H3-K9 Demethylation Histone H3-K36 Demethylation
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	HDMs demethylate histones Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Estrogen-dependent gene expression
Drugs
Diseases
GWAS			Granulocyte percentage of myeloid white cells ( 27863252) Hip circumference adjusted for BMI ( 34021172) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Periodontitis (CDC/AAP) ( 24024966) Pulse pressure ( 30578418) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549) Urate levels ( 31578528) Walking pace ( 33128006)
Interacting Genes		12 interacting genes: ABI2 ARHGDIG ESR1 ESR2 FUCA1 HNF4A KDM4B MOB4 NAP1L1 PEBP1 SYCE1L TRIM45	3 interacting genes: H3-5 MED10 TUBB4A
Entrez ID		84246	23030
HPRD ID		14680	11056
Ensembl ID		ENSG00000133398	ENSG00000127663
Uniprot IDs		Q9BTT4	A0A0C4DFL8 F5GX28 O94953
PDB IDs			4LXL 4UC4
Enriched GO Terms of Interacting Partners?
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