ZCCHC7 and PHC1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		ZCCHC7	PHC1
Description		zinc finger CCHC-type containing 7	polyhomeotic homolog 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytosol	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding
	Biological Process		Histone Ubiquitination Negative Regulation Of Transcription, DNA-templated
Pathways			Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Bitter beverage consumption ( 31046077) C-reactive protein levels ( 33339817) Chronotype ( 30696823) HIV-1 susceptibility ( 25786224) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Metabolite risk score for predicting weight gain ( 31560688) Morning person ( 30696823) Severe bacterial meningitis ( 31092817)	Antisaccade task score ( 31596458) Cholesterol, total ( 24097068) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Height ( 31562340) Prepulse inhibition of the startle response ( 31596458) Small cell lung carcinoma ( 28604730) Total cholesterol levels ( 28334899) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		13 interacting genes: CARD9 CREBBP GIPC2 KIF9 LCE1E NEK6 PHC1 SNIP1 SUMO1 SUMO2 TRIM41 UBE2I ZNF250	23 interacting genes: BMI1 FAM9A GMNN HSPA8 PCGF3 PHC2 PIAS2 PPP1CA PPP1CC RING1 RNF2 RNF4 SCMH1 SDCBP2 SFMBT1 SFMBT2 SIAH1 SP100 SUMO1 SUMO1P1 TET2 UBE2I ZCCHC7
Entrez ID		84186	1911
HPRD ID		15703	16009
Ensembl ID		ENSG00000147905	ENSG00000111752
Uniprot IDs		Q05DN1 Q8N3Z6	P78364 Q6GMQ3 Q6N083
PDB IDs			2L8E
Enriched GO Terms of Interacting Partners?
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