CHD6 and ARAF

Number of citations of the paper that reports this interaction (PubMedID 20936779)
88

Data Source:
BioGRID (two hybrid)

		CHD6	ARAF
Description		chromodomain helicase DNA binding protein 6	A-Raf proto-oncogene, serine/threonine kinase
Image
GO Annotations	Cellular Component	Nucleoplasm	Cellular_component Mitochondrion Cytosol
	Molecular Function	Transcription Coregulator Binding DNA Binding DNA Helicase Activity ATP Binding ATP-dependent Activity, Acting On DNA ATP Hydrolysis Activity ATP-dependent Chromatin Remodeler Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Chromatin Organization DNA Duplex Unwinding Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress	MAPK Cascade Cellular Protein Modification Process Protein Phosphorylation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Apoptotic Process
Pathways			RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling
Drugs			ATP
Diseases
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Diastolic blood pressure ( 27841878) Gastric adenocarcinoma (histologically verified) ( 26098866) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hippocampal atrophy ( 22745009) Low density lipoprotein cholesterol levels ( 32154731) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Refractive astigmatism ( 30306274) Systolic blood pressure ( 27841878) Total cholesterol levels ( 30275531) Triglyceride levels ( 32154731) Verbal declarative memory ( 25648963) Waist circumference ( 31170924)
Interacting Genes		6 interacting genes: ARAF ATXN1L H3-4 NFE2L2 TOLLIP ZFYVE9	58 interacting genes: AGTRAP AKT1 ASS1 BAD BECN1 BRAF CCND2 CDK4 CDK6 CDKN2B CHD6 COPS3 CPS1 CSNK2B DIDO1 E2F6 EFEMP1 EPHA2 FGFR4 GLIS2 GNA12 HRAS IRAK2 IRF7 KLHL12 LATS2 MAP2K1 MAP2K2 MAP2K3 MAP2K5 MLH1 MYC MYO18A NELFCD NF2 NRAS NUDT14 PBK PDGFRB PIK3CA PIK3R1 PKM PRPF6 RABGGTB RASSF1 RGS12 RRAS RRAS2 SFN STK11 TEKT4P2 TESK1 TIMM44 TIRAP TP53 TSC1 WNK1 YWHAG
Entrez ID		84181	369
HPRD ID		13049	02405
Ensembl ID		ENSG00000124177	ENSG00000078061
Uniprot IDs		Q8TD26	A0A024R178 P10398 Q96II5
PDB IDs		2EPB	1WXM 2MSE
Enriched GO Terms of Interacting Partners?
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