SLA2 and CSF1

Number of citations of the paper that reports this interaction (PubMedID 17353186)
12

Data Source:
BioGRID (pull down)

		SLA2	CSF1
Description		Src like adaptor 2	colony stimulating factor 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Late Endosome Golgi Apparatus Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Endosome Membrane Intracellular Membrane-bounded Organelle	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Membrane Integral Component Of Membrane Nuclear Body Perinuclear Region Of Cytoplasm CSF1-CSF1R Complex
	Molecular Function	Protein Binding Signaling Adaptor Activity 1-phosphatidylinositol-3-kinase Regulator Activity Protein N-terminus Binding	Cytokine Activity Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II B Cell Mediated Immunity T Cell Activation Regulation Of Phosphatidylinositol 3-kinase Activity Phosphatidylinositol Phosphate Biosynthetic Process Regulation Of Immune Response Negative Regulation Of Calcium-mediated Signaling Antigen Receptor-mediated Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway	Positive Regulation Of Cell-matrix Adhesion Osteoclast Proliferation Response To Ischemia Developmental Process Involved In Reproduction Inflammatory Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Macrophage Chemotaxis Macrophage Differentiation Regulation Of Ossification Osteoclast Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Mononuclear Cell Proliferation Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Monocyte Activation Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Ras Protein Signal Transduction Homeostasis Of Number Of Cells Within A Tissue Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Fat Development Mammary Duct Terminal End Bud Growth Microglial Cell Proliferation Negative Regulation Of Neuron Death Positive Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Microglial Cell Migration Positive Regulation Of Macrophage Migration
Pathways		Negative regulation of FLT3	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Other interleukin signaling Interleukin-10 signaling Post-translational protein phosphorylation
Drugs
Diseases
GWAS			Adult onset Still's disease ( 32149159) Aspartate aminotransferase levels ( 33547301 29403010 33339817) Blood protein levels in cardiovascular risk ( 28369058) Creatine kinase levels ( 29403010) Cryptococcosis in HIV infection ( 33269293) Height ( 31562340) High density lipoprotein cholesterol levels ( 33339817) Lactate dehydrogenase levels ( 29403010) Lymphocyte counts ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Paget's disease ( 21623375 20436471) Periventricular white matter hyperintensities ( 32517579) Platelet count ( 32888494) Plateletcrit ( 32888494) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954) Serum total protein level ( 29403010) Total body bone mineral density ( 29304378) White blood cell count ( 32888494 27863252)
Interacting Genes		14 interacting genes: CBL CD247 CSF1 EGFR ERBB2 ERBB3 ERBB4 GAB1 KIT LAMC2 MET PRKAA2 UBASH3A ZAP70	13 interacting genes: CSF1R CYSRT1 FHL3 GAB3 HLA-B KRTAP1-1 KRTAP10-8 MTUS2 NOTCH2NLA SGTA SLA2 SOCS1 TNF
Entrez ID		84174	1435
HPRD ID		05955	00388
Ensembl ID		ENSG00000101082	ENSG00000184371
Uniprot IDs		Q9H6Q3	A0A024R0A1 P09603
PDB IDs		4M4Z	1HMC 3UEZ 3UF2 4ADF 4FA8 4WRL 4WRM 5LXF
Enriched GO Terms of Interacting Partners?
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