FRMD8 and ZNF446

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FRMD8	ZNF446
Description		FERM domain containing 8	zinc finger protein 446
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Centriolar Satellite	Chromatin Extracellular Space Nucleus
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Canonical Wnt Signaling Pathway	Regulation Of Transcription By RNA Polymerase II
Pathways			Generic Transcription Pathway
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Alanine aminotransferase levels ( 33547301) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Refractive error ( 32231278) Serum uric acid levels ( 32514006 32271837) Urate levels ( 31578528)	Obesity-related traits ( 23251661) Uric acid clearance ( 28095793)
Interacting Genes		9 interacting genes: APP FATE1 GRAMD2B IKBKG KCNH2 LIME1 PLEKHF2 ZNF446 ZNF474	60 interacting genes: ACTN2 ANKRD1 CCNK COPS2 CYSRT1 DGCR6 DGCR6L EHMT2 EVI5 FHL5 FRMD8 FRS3 GOLGA6L9 INCA1 KIFC3 KRT31 KRT34 KRT35 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP3-1 LNX1 LZTS2 MAGOHB MDFI NBPF19 NOTCH2NLA PGBD1 PIN1 REL SCAND1 SIVA1 SUFU TAX1BP1 TRIM27 UBE2I UBE3A ZKSCAN4 ZKSCAN7 ZNF165 ZNF18 ZNF232 ZNF24 ZNF263 ZNF396 ZNF397 ZNF483 ZNF496 ZSCAN12 ZSCAN16 ZSCAN18 ZSCAN21 ZSCAN22 ZSCAN23 ZSCAN29 ZSCAN30 ZSCAN32 ZSCAN9
Entrez ID		83786	55663
HPRD ID		13326	07934
Ensembl ID		ENSG00000126391	ENSG00000083838
Uniprot IDs		A8K6L3 Q9BZ67	Q8NDK2 Q9NWS9 Q9UFF2
PDB IDs
Enriched GO Terms of Interacting Partners?
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