ATG10 and IRGM

Number of citations of the paper that reports this interaction (PubMedID 22174682)
95

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		ATG10	IRGM
Description		autophagy related 10	immunity related GTPase M
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	Golgi Membrane Autophagosome Membrane Phagocytic Cup Mitochondrion Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Phagocytic Vesicle Membrane Cell Projection
	Molecular Function	Protein Binding Atg12 Transferase Activity	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity CARD Domain Binding BH3 Domain Binding
	Biological Process	Protein Lipidation Autophagy ER Overload Response Protein Transport Macroautophagy Positive Regulation Of Protein Modification Process Protein Modification By Small Protein Conjugation	Autophagosome Assembly Positive Regulation Of Protein Phosphorylation Defense Response Inflammatory Response Positive Regulation Of Autophagy Positive Regulation Of Peptidyl-threonine Phosphorylation Protein Destabilization Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interferon-beta Defense Response To Bacterium Regulation Of Protein-containing Complex Assembly Innate Immune Response Protein Stabilization Defense Response To Gram-negative Bacterium Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Protein Complex Stability Protein Lipidation Involved In Autophagosome Assembly CAMKK-AMPK Signaling Cascade Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation By Symbiont Of Host Autophagy Cellular Response To Virus Positive Regulation Of Autophagosome Maturation
Pathways		Macroautophagy Macroautophagy
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Airway imaging phenotypes ( 26030696) Breast cancer ( 25751625 29059683) Carotid intima media thickness (mean) ( 31801372) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels in HIV infection ( 33109212)	Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 17554261 17554300 21102463) Dimensional psychopathology (Arousal) ( 29496196) Inflammatory bowel disease ( 28067908 23128233)
Interacting Genes		5 interacting genes: ATG12 ATG5 ATG7 DNAI1 IRGM	5 interacting genes: ATG10 ATG5 MAP1LC3C NOD2 SH3GLB1
Entrez ID		83734	345611
HPRD ID		16497	19559
Ensembl ID		ENSG00000152348	ENSG00000237693
Uniprot IDs		Q9H0Y0	A1A4Y4
PDB IDs
Enriched GO Terms of Interacting Partners?
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