JAM3 and F2RL2

Number of citations of the paper that reports this interaction (PubMedID 12953056)
80

Data Source:
HPRD (in vivo, in vitro)

		JAM3	F2RL2
Description		junctional adhesion molecule 3	coagulation factor II thrombin receptor like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cell-cell Junction Bicellular Tight Junction Desmosome Filamentous Actin Paranodal Junction Schmidt-Lanterman Incisure Cell-cell Contact Zone Tight Junction Protein Complex Involved In Cell Adhesion	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Protein-containing Complex
	Molecular Function	Integrin Binding Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Cell-cell Adhesion Mediator Activity	Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding Thrombin-activated Receptor Activity
	Biological Process	Angiogenesis Neutrophil Homeostasis Adaptive Immune Response Myeloid Progenitor Cell Differentiation Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Cellular Extravasation Cell-matrix Adhesion Spermatid Development Transmission Of Nerve Impulse Establishment Of Cell Polarity Axon Regeneration Negative Regulation Of Integrin Activation Negative Regulation Of Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Adherens Junction Assembly Protein Localization To Cell Surface Maintenance Of Blood-brain Barrier Myelination Apical Protein Localization Regulation Of Neutrophil Chemotaxis Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Hematopoietic Stem Cell Migration To Bone Marrow Granulocyte Migration Cell-cell Adhesion Protein Localization To Cell Junction Positive Regulation Of Membrane Permeability	Blood Coagulation Response To Wounding Platelet Activation Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Thrombin-activated Receptor Signaling Pathway
Pathways		Cell surface interactions at the vascular wall Integrin cell surface interactions	Peptide ligand-binding receptors G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Neutrophil count ( 32888494)	Mean platelet volume ( 28031487) Phenylephrine infusion rate during anesthesia ( 31455332)
Interacting Genes		8 interacting genes: F2RL2 ITGAM ITGAX JAM2 MEOX2 PICK1 RHOU TJP1	9 interacting genes: AMT CDH5 CTSG ECT2 F11R F2 F2RL3 JAM2 JAM3
Entrez ID		83700	2151
HPRD ID		06042	03561
Ensembl ID		ENSG00000166086	ENSG00000164220
Uniprot IDs		Q9BX67	O00254
PDB IDs
Enriched GO Terms of Interacting Partners?
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