NUDT12 and CAMK4

		NUDT12	CAMK4
Description		nudix hydrolase 12	calcium/calmodulin dependent protein kinase IV
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GO Annotations	Cellular Component	Nucleus Cytoplasm Peroxisome Peroxisomal Matrix Cytosol	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	NAD+ Diphosphatase Activity Magnesium Ion Binding Protein Binding Zinc Ion Binding NADH Pyrophosphatase Activity RNA NAD-cap (NMN-forming) Hydrolase Activity Phosphodiesterase Decapping Endonuclease Activity	Calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity
	Biological Process	MRNA Catabolic Process NADH Metabolic Process NADP Catabolic Process NAD Catabolic Process Circadian Regulation Of Gene Expression NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway RNA Phosphodiester Bond Hydrolysis, Endonucleolytic NAD-cap Decapping Methylguanosine-cap Decapping	Adaptive Immune Response Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Protein Phosphorylation Inflammatory Response Signal Transduction Long-term Memory Peptidyl-serine Phosphorylation Regulation Of T Cell Differentiation In Thymus Intracellular Signal Transduction Myeloid Dendritic Cell Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation
Pathways		Nicotinamide salvaging	CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB Transcriptional activation of mitochondrial biogenesis CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity Negative regulation of NMDA receptor-mediated neuronal transmission
Drugs			K-00546 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one
Diseases
GWAS		Academic attainment (English) ( 33594131) Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Blood protein levels ( 29875488) Body size at age 10 ( 32376654) Depression (quantitative trait) ( 23290196) Fasting glucose change ( 31263163) Gut microbiota (functional units) ( 27694959) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Longevity ( 30294719) Mitochondrial DNA levels ( 25240745) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Response to fenofibrate (total cholesterol levels) ( 27002377) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Triglyceride levels ( 32203549)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Allergy ( 27182965) Alzheimer's disease (cognitive decline) ( 23535033) Asthma ( 31959851 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid disease ( 32581359) Blood pressure ( 17903302) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Motor coordination ( 34177493) Periodontitis (PAL4Q3) ( 24024966) Self-reported allergy ( 23817569) Type 1 diabetes ( 34012112)
Interacting Genes		3 interacting genes: BLMH CAMK4 RPGR	11 interacting genes: CABIN1 CAMKK1 CAMKK2 CREBBP GAPDH HDAC4 NEDD4 NOS1 NOTCH1 NUDT12 RELA
Entrez ID		83594	814
HPRD ID		10123	07169
Ensembl ID		ENSG00000112874	ENSG00000152495
Uniprot IDs		Q9BQG2	Q16566
PDB IDs		6SCX	2W4O
Enriched GO Terms of Interacting Partners?
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