CDCA3 and WEE1

Number of citations of the paper that reports this interaction (PubMedID 12679038)
56

Data Source:
HPRD (in vivo, in vitro)

		CDCA3	WEE1
Description		cell division cycle associated 3	WEE1 G2 checkpoint kinase
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Adherens Junction	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Protein Binding	Magnesium Ion Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Cell Cycle Biological_process Protein Ubiquitination Cell Division	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Peptidyl-tyrosine Phosphorylation Establishment Of Cell Polarity Neuron Projection Morphogenesis Cell Division Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Polo-like kinase mediated events Cyclin E associated events during G1/S transition Cyclin A/B1/B2 associated events during G2/M transition Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Cyclin A:Cdk2-associated events at S phase entry Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Factors involved in megakaryocyte development and platelet production
Drugs			9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONE 9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE N-[4-(2-CHLOROPHENYL)-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-C]CARBAZOL-9-YL]FORMAMIDE 4-(2-chlorophenyl)-8-(2-hydroxyethyl)-6-methylpyrrolo[3,4-e]indole-1,3(2H,6H)-dione 3-(9-HYDROXY-1,3-DIOXO-4-PHENYL-2,3-DIHYDROPYRROLO[3,4-C]CARBAZOL-6(1H)-YL)PROPANOIC ACID 8-bromo-4-(2-chlorophenyl)-N-(2-hydroxyethyl)-6-methyl-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-e]indole-7-carboxamide MK-1775 Fostamatinib
Diseases
GWAS			Cutaneous squamous cell carcinoma ( 32041948) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Platelet distribution width ( 32888494)
Interacting Genes		10 interacting genes: APP BCL11A CTDSP1 CTDSP2 CTDSPL CUL1 SKP1 TRAF1 TRAF2 WEE1	23 interacting genes: BRD8 BRSK1 BRSK2 BTRC CASP3 CDCA3 CDK1 CDK2 CRK CSNK2A1 ERRFI1 FBXW11 MAILR NEDD4 PIN1 PLK1 SKP2 SMAD3 SMURF1 YWHAB YWHAG YWHAQ YWHAZ
Entrez ID		83461	7465
HPRD ID		09670	01907
Ensembl ID		ENSG00000111665	ENSG00000166483
Uniprot IDs		F5GX58 F8WDL1 J3KMY0 Q99618	P30291 Q86V29
PDB IDs			1X8B 2IN6 2IO6 2Z2W 3BI6 3BIZ 3CQE 3CR0 5V5Y 5VC3 5VC4 5VC5 5VC6 5VD2 5VD4 5VD5 5VD7 5VD8 5VD9 5VDA
Enriched GO Terms of Interacting Partners?
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