FZD1 and WNT3

Number of citations of the paper that reports this interaction (PubMedID 10557084)
35

Data Source:
HPRD (in vivo)

		FZD1	WNT3
Description		frizzled class receptor 1	Wnt family member 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Wnt Signalosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Endocytic Vesicle Membrane Extracellular Matrix Extracellular Exosome Wnt Signalosome
	Molecular Function	G Protein-coupled Receptor Activity Signaling Receptor Binding Frizzled Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Wnt-activated Receptor Activity	Frizzled Binding Cytokine Activity Protein Binding Protein Domain Specific Binding Receptor Ligand Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Xenobiotic Stimulus Positive Regulation Of Neuron Projection Development Neuron Differentiation Autocrine Signaling Non-canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Canonical Wnt Signaling Pathway Involved In Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of DNA-binding Transcription Factor Activity Canonical Wnt Signaling Pathway Presynapse Assembly Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation	Cell Morphogenesis Mesoderm Formation Gamete Generation Axon Guidance Anterior/posterior Axis Specification Dorsal/ventral Axis Specification Positive Regulation Of Gene Expression Positive Regulation Of Wnt Signaling Pathway Neuron Differentiation Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Canonical Wnt Signaling Pathway Involved In Osteoblast Differentiation Cell Fate Commitment Positive Regulation Of Collateral Sprouting In Absence Of Injury Negative Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Neurogenesis Spemann Organizer Formation At The Anterior End Of The Primitive Streak Canonical Wnt Signaling Pathway Limb Bud Formation Head Morphogenesis Mammary Gland Epithelium Development Cellular Response To Retinoic Acid Stem Cell Proliferation Canonical Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation Canonical Wnt Signaling Pathway Involved In Stem Cell Proliferation
Pathways		TCF dependent signaling in response to WNT Class B/2 (Secretin family receptors) PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane	TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Dental caries ( 23259602) Pulse pressure ( 27841878) Schizophrenia ( 31735061) Systolic blood pressure ( 27841878)	Alcohol consumption (drinks per week) ( 30679032) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease in APOE e4- carriers ( 25778476) Atrial fibrillation ( 30061737) Body mass index ( 26426971) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 28093568) Cortical surface area (global PC1) ( 32198502) Cortical thickness ( 32963231) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Handedness (Left-handed vs. non-left-handed) ( 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Handedness (non-right-handed vs right-handed) ( 31504236) Hematocrit ( 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29785010) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Male-pattern baldness ( 29146897 28196072) Mood instability ( 31168069) Multiple system atrophy ( 27629089) Nonsyndromic cleft lip with or without cleft palate ( 33898419) Parkinson's disease ( 22451204 21812969) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Post bronchodilator FEV1 ( 26634245) Reaction time ( 29844566) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: DLG2 DLG4 WNT2 WNT3 WNT3A WNT5A	2 interacting genes: FZD1 TUBG1
Entrez ID		8321	7473
HPRD ID		04558	01318
Ensembl ID		ENSG00000157240	ENSG00000108379
Uniprot IDs		Q9UP38	P56703
PDB IDs			6AHY
Enriched GO Terms of Interacting Partners?
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