ABHD17A and HPGDS

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		ABHD17A	HPGDS
Description		abhydrolase domain containing 17A, depalmitoylase	hematopoietic prostaglandin D synthase
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Endosome Membrane Membrane Nuclear Speck Dendritic Spine Intracellular Membrane-bounded Organelle Recycling Endosome Membrane Glutamatergic Synapse Anchored Component Of Postsynaptic Density Membrane Anchored Component Of Postsynaptic Recycling Endosome Membrane	Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Palmitoyl-(protein) Hydrolase Activity	Magnesium Ion Binding Glutathione Transferase Activity Prostaglandin-D Synthase Activity Calcium Ion Binding Protein Binding Protein Homodimerization Activity
	Biological Process	Protein Depalmitoylation Protein Localization To Membrane Regulation Of Postsynapse Organization Negative Regulation Of Protein Localization To Microtubule Positive Regulation Of Protein Localization To Endosome	Prostaglandin Biosynthetic Process Prostaglandin Metabolic Process Glutathione Metabolic Process Signal Transduction Locomotory Behavior
Pathways		RAS processing	Glutathione conjugation Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs			Glutathione Tretinoin 2-(2f-Benzothiazolyl)-5-Styryl-3-(4f-Phthalhydrazidyl)Tetrazolium Chloride Glutathione disulfide 3-phenyl-5-(1H-pyrazol-3-yl)isoxazole PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE Tranilast 4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid 4-(BENZHYDRYLOXY)-1-[3-(1H-TETRAAZOL-5-YL)PROPYL]PIPERIDINE Nocodazole 3-(4-nitrophenyl)-1H-pyrazole 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
Diseases
GWAS			Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Blood protein levels ( 30072576 29875488) Testicular germ cell tumor ( 28604728 28604732 23666239)
Interacting Genes		14 interacting genes: BIRC2 DLG4 EHMT2 GOLGA2 GPC4 HPGDS KRTAP5-9 MDFI PLSCR4 PNMA1 RGS20 TNIP1 TRAF1 TRIM27	7 interacting genes: ABHD17A ARRDC3 C14orf39 HK3 LIF MELTF PDE3B
Entrez ID		81926	27306
HPRD ID		07475	04001
Ensembl ID		ENSG00000129968	ENSG00000163106
Uniprot IDs		Q96GS6	A0A384P5J0 O60760
PDB IDs			1IYH 1IYI 1V40 2CVD 2VCQ 2VCW 2VCX 2VCZ 2VD0 2VD1 3EE2 3KXO 3VI5 3VI7 4EC0 4EDY 4EDZ 4EE0 5AIS 5AIV 5AIX 5YWE 5YWX 5YX1 6N4E 6W58 6W8H
Enriched GO Terms of Interacting Partners?
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