NPRL3 and SESN3

Number of citations of the paper that reports this interaction (PubMedID 25263562)
166

Data Source:
BioGRID (pull down)

		NPRL3	SESN3
Description		NPR3 like, GATOR1 complex subunit	sestrin 3
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane GATOR1 Complex	Nucleus Cytoplasm TORC2 Complex
	Molecular Function	GTPase Activator Activity Protein Binding	Protein Binding Oxidoreductase Activity, Acting On Peroxide As Acceptor Leucine Binding
	Biological Process	Ventricular Septum Development Negative Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Aorta Morphogenesis TORC1 Signaling Cardiac Muscle Tissue Development Regulation Of Catalytic Activity Roof Of Mouth Development Regulation Of Autophagosome Assembly	Positive Regulation Of Macroautophagy Response To Insulin Cellular Response To Amino Acid Starvation TORC2 Signaling Cellular Response To Glucose Starvation Glucose Homeostasis Regulation Of Insulin Receptor Signaling Pathway Regulation Of Protein Kinase B Signaling Cellular Response To Leucine Regulation Of Response To Reactive Oxygen Species Negative Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation
Pathways		Amino acids regulate mTORC1	TP53 Regulates Metabolic Genes
Drugs
Diseases
GWAS		Cardiometabolic and hematological traits ( 27668658) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693 26366553) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 29403010 32888494 28453575 27863252) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 28453575 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 29403010 32888494 27863252) Red blood cell traits ( 23446634 23222517) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Serum metabolite levels ( 33031748) Sickle cell anemia (haemolysis) ( 23406172)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Aspartate aminotransferase levels ( 33547301) Chronotype ( 30696823) Common carotid intima-media thickness ( 29206233) Common carotid intima-media thickness in HIV infection ( 29206233) Diastolic blood pressure ( 27841878) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		3 interacting genes: APPBP2 FHL3 SESN3	4 interacting genes: MIOS NPRL3 WDR24 WDR59
Entrez ID		8131	143686
HPRD ID		11866	09682
Ensembl ID		ENSG00000103148	ENSG00000149212
Uniprot IDs		B7Z220 B7Z6Q0 Q12980 Q9BTE2	P58005
PDB IDs		6CES 6CET
Enriched GO Terms of Interacting Partners?
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