HMGA2 and XRCC6

Number of citations of the paper that reports this interaction (PubMedID 18850631)
12

Data Source:
BioGRID (pull down, far western blotting)

		HMGA2	XRCC6
Description		high mobility group AT-hook 2	X-ray repair cross complementing 6
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Nucleus Nucleoplasm Protein-DNA Complex Senescence-associated Heterochromatin Focus SMAD Protein Complex	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Extracellular Region Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytosol Membrane Protein-containing Complex Protein-DNA Complex Secretory Granule Lumen Ku70:Ku80 Complex Nonhomologous End Joining Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Transcription Cis-regulatory Region Binding Minor Groove Of Adenine-thymine-rich DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding Transcription Factor Binding DNA Binding, Bending Enzyme Binding Nucleosomal DNA Binding CAMP Response Element Binding MH2 Domain Binding MH1 Domain Binding SMAD Binding 5'-deoxyribose-5-phosphate Lyase Activity C2H2 Zinc Finger Domain Binding	Transcription Cis-regulatory Region Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding RNA Binding Protein Binding ATP Binding Protein C-terminus Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity Cyclin Binding Telomeric DNA Binding Protein-containing Complex Binding DNA End Binding 5'-deoxyribose-5-phosphate Lyase Activity Scaffold Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Epithelial To Mesenchymal Transition Chondrocyte Differentiation Mesodermal-endodermal Cell Signaling Base-excision Repair Chromatin Organization Regulation Of Transcription, DNA-templated Mitotic G2 DNA Damage Checkpoint Signaling Multicellular Organism Development Response To Virus Regulation Of Cell Cycle Process Positive Regulation Of Gene Expression Chromosome Condensation Chromosome Breakage Heterochromatin Assembly Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Histone H2A-S139 Phosphorylation Endodermal Cell Differentiation Chondrocyte Proliferation Regulation Of Growth DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation By Host Of Viral Transcription Fat Cell Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Mesodermal Cell Differentiation Mesenchymal Cell Differentiation Stem Cell Differentiation Positive Regulation Of DNA-binding Transcription Factor Activity Cell Division Regulation Of Cell Cycle Positive Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of Protein Serine/threonine Kinase Activity Oncogene-induced Cell Senescence Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Cellular Response To X-ray Negative Regulation Of Cellular Senescence Positive Regulation Of Cellular Senescence Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Cellular Response To Drug	Telomere Maintenance Activation Of Innate Immune Response DNA Ligation Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Brain Development DNA Duplex Unwinding Innate Immune Response Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Smooth Muscle Cell Proliferation Cellular Hyperosmotic Salinity Response Cellular Response To Gamma Radiation Cellular Response To X-ray Double-strand Break Repair Via Classical Nonhomologous End Joining
Pathways		Formation of Senescence-Associated Heterochromatin Foci (SAHF)	2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678) Aortic root size ( 19584346) Axial length ( 24144296) Birth length ( 25281659) Birth weight ( 23202124 31043758 27680694) Body size at age 10 ( 32376654) Brain structure ( 22504417) Childhood body mass index ( 33045005) Chin dimples ( 27182965) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Cortical surface area (global PC1) ( 32198502) Cortical volume ( 32963231) Fasting insulin ( 34059833) Haemorrhoidal disease ( 33888516) Head circumference (infant) ( 22504419) Heart rate response to exercise ( 29769521) Heel bone mineral density ( 30598549) Height ( 21998595 28552196 20881960 22021425 25282103 25429064 19343178 23563607 31562340 18391950 18391951 18391952 20397748 17767157) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172 25673412) Hip index ( 34021172) Infant length ( 25281659) Late-onset Alzheimer's disease ( 27770636) Medication use (drugs used in diabetes) ( 31015401) Neutrophil count ( 32888494) Offspring birth weight ( 31043758) Permanent tooth development ( 21931568) Plateletcrit ( 32888494) Polycystic ovary syndrome ( 22885925) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 31928498) Triglyceride levels ( 32203549) Type 2 diabetes ( 22885922 24509480 30054458 26961502 29358691 25102180 30297969 32499647 20581827 28869590) Type 2 diabetes nephropathy ( 21150874) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Youthful appearance (self-reported) ( 32339537)	Asthma ( 34103634) Breast cancer ( 29059683) Meat-related diet ( 32066663) Neuroticism ( 29255261) Pulse pressure ( 28135244) Refractive error ( 32231278)
Interacting Genes		22 interacting genes: APEX1 CDK1 CSNK2A1 CSNK2A2 E4F1 KAT2B MDM2 NFKB1 NPM1 PA2G4 PCBP2 PIAS3 PRKCA PRMT6 PSIP1 PTBP1 RB1 RELA SMAD3 SYNCRIP TP53 XRCC6	135 interacting genes: ABCD4 ABL1 ACD ADCY7 APEX1 AR ARAP1 ATP23 ATP6V1E1 BARD1 BAZ1A BTG1 CAPN11 CBX5 CCNA1 CCT3 CD40 CDCA5 CDK2 CDKN1A CEBPA CENPU CHAF1A CHEK1 CLTC CLU CMTM6 COIL COPB1 CREBBP CSNK2A1 CTBP2 DLX2 DNTT DUX4 DYSF EFNA1 EGFR EID1 ELF3 EP300 EPS8 ETS1 FMNL1 GAL3ST4 GSE1 GZMA GZMB HERPUD1 HMGA2 HOXB7 HOXC4 HOXD4 HSF1 HTT ILVBL JPT2 KAT2A KAT2B KIAA0408 LIG3 MAP2K5 MAP4K2 MAPK8 MRE11 MSX2 NAA15 NCF4 NCL NCOA6 NIT1 NOTCH1 OGT PAEP PAFAH1B3 PARP1 PCNA PDK1 PDPK1 PDX1 PECAM1 PGAM1 PGR PIN1 PLGRKT PNRC2 POR POU2F1 POU2F2 PRKDC PRPF40A PTEN PTTG1 QRSL1 RASA1 RBBP4 RGS2 RNF126 RNF146 RPLP1 RPS10 RRAS2 RUNX2 SDHC SELENOF SERPINA2 SERPINB9 SET SGO1 SIRT3 SKIL SMAD3 SMAD7 SNTA1 SNU13 SPARC SUMO2 TAC1 TADA3 TBCD TCF4 TERF2 TERT TOP1 TP53 UBC USP14 VAV1 VBP1 WBP4 WRN XRCC5 YWHAZ ZBTB7A ZNF512B
Entrez ID		8091	2547
HPRD ID		02827	01071
Ensembl ID		ENSG00000149948	ENSG00000196419
Uniprot IDs		F5H2A4 F5H6H0 P52926 Q1M183	A0A024R1N4 B1AHC9 B4DE32 B4E356 P12956
PDB IDs			1JEQ 1JEY 1JJR 3RZX 5Y3R 6ERF 6ERG 6ERH 6ZHA 6ZHE 7AXZ 7K0Y 7K1J 7K1K 7K1N
Enriched GO Terms of Interacting Partners?
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