FXR1 and VWF

Number of citations of the paper that reports this interaction (PubMedID 21653829)
98

Data Source:
BioGRID (two hybrid)

		FXR1	VWF
Description		FMR1 autosomal homolog 1	von Willebrand factor
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Polysome Postsynaptic Density Membrane Axon Growth Cone Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Costamere Dendritic Spine Dendritic Spine Neck Perinuclear Region Of Cytoplasm Presynapse Glutamatergic Synapse Dendritic Filopodium	Extracellular Region Extracellular Space Endoplasmic Reticulum Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Weibel-Palade Body Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding RNA Strand Annealing Activity Protein Homodimerization Activity Translation Regulator Activity Protein Heterodimerization Activity	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Immunoglobulin Binding Identical Protein Binding Protein N-terminus Binding Chaperone Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Phosphorylation Apoptotic Process Muscle Organ Development Negative Regulation Of Translation Cell Differentiation Regulation Of MRNA Stability Positive Regulation Of Translation Regulation Of Filopodium Assembly Skeletal Muscle Organ Development Positive Regulation Of Gene Silencing By MiRNA Positive Regulation Of Response To DNA Damage Stimulus	Cell Adhesion Blood Coagulation Hemostasis Response To Wounding Platelet Activation Cell-substrate Adhesion Positive Regulation Of Intracellular Signal Transduction
Pathways		Signaling by BRAF and RAF1 fusions	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins GP1b-IX-V activation signalling MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) Signaling downstream of RAS mutants Signaling by RAF1 mutants Defective F8 cleavage by thrombin Defective F8 binding to von Willebrand factor
Drugs			Antihemophilic factor, human recombinant Egaptivon pegol Caplacizumab Simoctocog alfa Antihemophilic Factor (Recombinant), PEGylated Susoctocog alfa Efmoroctocog alfa Lonoctocog alfa Moroctocog alfa
Diseases
GWAS		Bipolar disorder and eating disorder ( 26433762) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Eating disorder in bipolar disorder ( 26433762) Mastocytosis ( 32752121) Metabolite levels ( 23823483) Schizophrenia ( 25056061 19571811 29483656 30285260)	Blood protein levels ( 29875488) Coagulation factor levels ( 23267103) Factor VIII levels ( 20231535 30586737) Low vWF levels ( 26486471) Mean platelet volume ( 22139419 32888494 27863252) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Platelet count ( 26805783 22139419 32888494) Response to tofacitinib treatment in psoriasis (herpes zoster) ( 33455090) Response to tofacitinib treatment in psoriasis (herpes zoster)(time to event) ( 33455090) Venous thromboembolism ( 31420334) vWF levels ( 20231535 30586737) vWF levels in ischaemic stroke and hyperhomocysteinaemia ( 28495826)
Interacting Genes		266 interacting genes: ABI1 ACLY ACOT7 ACTB ACTG1 ACTN1 ACTN2 ADAMTSL4 AHCY ALAS1 ANKRD40 ANKS3 AP1M1 APC2 ARHGAP22 ARHGEF7 ATN1 AXIN1 AXIN2 BCKDK BEND5 BHLHE40 BICD1 BLK BTBD2 BTBD6 BYSL C1orf35 C1QBP CA10 CACTIN-AS1 CALCOCO1 CAMK2A CAMK2B CAMK2G CAPN3 CAPRIN1 CBS CBX8 CCAR2 CCBE1 CCDC187 CCDC92 CCN3 CD86 CDC123 CDC7 CDKL3 CDR2 CDYL CEP126 CEP72 CEP89 CHRD CIR1 COIL CORO1A CORO1B CORO6 CPLANE1 CRMP1 CSNK2A1 CSNK2B CWF19L2 CYFIP2 CYHR1 DCTD DCTN1 DCTN2 DCTPP1 DEAF1 DHX15 DNAJA3 DNM2 ECH1 ECHS1 ECM1 EDC4 EFEMP2 EGFL7 EIF3A ELOA ENO1 ERCC6 ERG28 ERVFRD-1 ESCO2 EVL FAM161A FAM90A1 FBLN1 FBXO4 FLAD1 FLNB FMR1 FTH1 FXR2 GBP2 GFAP GLYR1 GOLGA2 GOLGA3 GPSM2 GRIP1 GRIP2 GRIPAP1 HIVEP1 HLA-DRB5 HMG20A HNRNPH2 HNRNPM HNRNPUL1 HOMER2 HOMER3 HPRT1 HSPB1 IK IL1RAP IMPDH2 INA JAKMIP1 KAZN KCNN1 KCTD1 KCTD13 KHDRBS1 KHDRBS3 KIAA1549L KIF17 KIF9 KRT18 LAP3 LNX1 LPP LRIF1 LRSAM1 LUC7L2 LZTS2 MAD1L1 MAGED1 MAGOH MAGOHB MAPK7 MAPK8IP3 MAPKBP1 MBIP MCRS1 MFAP1 MLLT1 MOAP1 MRPL19 MSANTD3 MTUS2 MVP MX1 MYH10 MYH9 MYO5B N4BP3 NBPF15 NECAB2 NECAB3 NEFL NKD2 NME1 NME1-NME2 NME3 P3H2 PAFAH1B3 PAICS PCCB PCED1A PDE9A PHC1P1 PHC2 PHLDB1 PKM PML PNMA1 POLR2H PPHLN1 PPP1R12C PRAM1 PRKCSH PRMT1 PRPF31 PRR13 PRSS23 PSMC3 PSMC5 PSME1 PSME3 PSPC1 PYCR1 PYCR2 PYCR3 RABAC1 RALYL RBM26 RBM45 RCBTB2 RPIA RUSC2 SAFB2 SAMD1 SCMH1 SEPTIN2 SERINC5 SERTAD1 SF3B2 SFPQ SH3GL2 SH3GLB2 SHANK1 SHARPIN SLC48A1 SLIT1 SNURF SORBS3 SOX5 SPECC1 SPRY1 SPRY2 SRPK2 SSNA1 SST STK16 STUB1 SUFU SYT6 TACC2 TASOR2 TBC1D22B TCEA2 TDRD7 TLE5 TMPO TNFAIP1 TNIP1 TRAF2 TRAP1 TRIM3 TRIOBP TRPM1 TSN TTLL5 TUBB UBAP2L UBP1 UHRF1BP1L USP46 UXS1 VIM VPS51 VWF WASH6P WRNIP1 YES1 YY1AP1 ZMAT2 ZNF212 ZNF417 ZNF423 ZNF438 ZNF71 ZNF821	22 interacting genes: ADAMTS13 ATXN7 CACNA1A CALR COL1A1 COL1A2 COL3A1 F8 FURIN FXR1 GP1BA HOXA1 HSPA5 ITGA2B MAP3K3 NOMO1 NUFIP2 P4HB RAC1 SOCS4 TNFRSF11B ZNF512B
Entrez ID		8087	7450
HPRD ID		02892	01906
Ensembl ID		ENSG00000114416	ENSG00000110799
Uniprot IDs		A0A0F7KYT8 A0A0F7L1S3 P51114	P04275
PDB IDs		2CPQ 3KUF 3O8V	1AO3 1ATZ 1AUQ 1FE8 1FNS 1IJB 1IJK 1M10 1OAK 1SQ0 1U0N 1UEX 2ADF 2MHP 2MHQ 3GXB 3HXO 3HXQ 3PPV 3PPW 3PPX 3PPY 3ZQK 4C29 4C2A 4C2B 4DMU 4NT5 5BV8 6FWN 6N29
Enriched GO Terms of Interacting Partners?
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