FGF23 and FGFR3

Number of citations of the paper that reports this interaction (PubMedID 12032146)
42

Data Source:
HPRD (in vitro)

		FGF23	FGFR3
Description		fibroblast growth factor 23	fibroblast growth factor receptor 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen	Extracellular Region Nucleus Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Transport Vesicle Receptor Complex
	Molecular Function	Fibroblast Growth Factor Receptor Binding Type 1 Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Fibroblast Growth Factor Binding Identical Protein Binding
	Biological Process	MAPK Cascade Positive Regulation Of Protein Phosphorylation Phosphate-containing Compound Metabolic Process Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Animal Organ Morphogenesis Positive Regulation Of Gene Expression Regulation Of Phosphate Transport Positive Regulation Of Vitamin D 24-hydroxylase Activity Cell Differentiation Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Cellular Phosphate Ion Homeostasis Response To Magnesium Ion Vitamin D Catabolic Process Cellular Response To Leptin Stimulus Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Hormone Secretion Phosphate Ion Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Vitamin D Cellular Response To Interleukin-6 Cellular Response To Parathyroid Hormone Stimulus Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Response To Sodium Phosphate	MAPK Cascade Skeletal System Development Endochondral Ossification Chondrocyte Differentiation Endochondral Bone Growth Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Peptidyl-tyrosine Phosphorylation Bone Mineralization Positive Regulation Of Kinase Activity Chondrocyte Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Protein Autophosphorylation Negative Regulation Of Developmental Growth Bone Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Bone Maturation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway
Pathways		PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR1c and Klotho ligand binding and activation FGFR2c ligand binding and activation FGFR3 mutant receptor activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR3 point mutants in cancer Post-translational protein phosphorylation	Signaling by activated point mutants of FGFR3 FGFR3 mutant receptor activation t(4;14) translocations of FGFR3 Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer
Drugs			XL999 Pazopanib Ponatinib Lenvatinib Nintedanib Fostamatinib Erdafitinib Pemigatinib Selpercatinib
Diseases
GWAS		Colorectal cancer ( 23263487) Migraine ( 27182965) Phosphorus levels ( 29403010 20558539)	Bladder cancer ( 24163127 20972438) Blood protein levels ( 30072576) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Urinary bladder cancer ( 20348956)
Interacting Genes		4 interacting genes: ERC1 FGFR2 FGFR3 PHEX	49 interacting genes: ADD1 ANOS1 ARAP1 ATF3 BORA C6orf47 CCDC17 CEP126 CHGB CTSK EPHA4 ERBB2 FGF1 FGF17 FGF18 FGF2 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 GMPS GPSM3 GRB2 GRK4 GTF3C1 HBZ HNRNPL IDUA IRF2BPL KRT8 NDUFS6 NECTIN1 POLA2 PTK2B RADIL RNF130 RPL8 RPS6KA3 SH2B1 SLC25A6 SMG7 SRPK2 STAT1 STAT3 STK32B
Entrez ID		8074	2261
HPRD ID		05648	00624
Ensembl ID		ENSG00000118972	ENSG00000068078
Uniprot IDs		Q9GZV9	P22607 Q0IJ44
PDB IDs		2P39 5W21 6S22	1RY7 2LZL 4K33 6LVM 6PNX 7DHL
Enriched GO Terms of Interacting Partners?
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