PDHX and PDK2

Number of citations of the paper that reports this interaction (PubMedID 12816949)
8

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		PDHX	PDK2
Description		pyruvate dehydrogenase complex component X	pyruvate dehydrogenase kinase 2
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Mitochondrial Pyruvate Dehydrogenase Complex
	Molecular Function	Protein Binding Acyltransferase Activity Pyruvate Dehydrogenase (NAD+) Activity	Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Protein Homodimerization Activity
	Biological Process	Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate	Glucose Metabolic Process Regulation Of Gluconeogenesis Protein Phosphorylation Regulation Of PH Insulin Receptor Signaling Pathway Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Cellular Ketone Metabolic Process Regulation Of Glucose Metabolic Process Cellular Response To Nutrient Cellular Response To Reactive Oxygen Species Glucose Homeostasis Regulation Of Calcium-mediated Signaling Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid
Drugs			4-({(2R,5S)-2,5-DIMETHYL-4-[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]PIPERAZIN-1-YL}CARBONYL)BENZONITRILE (2R)-N-{4-[Ethyl(phenyl)sulfamoyl]-2-methylphenyl}-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide N-(2-AMINOETHYL)-2-{3-CHLORO-4-[(4-ISOPROPYLBENZYL)OXY]PHENYL} ACETAMIDE
Diseases
GWAS		Bone mineral density (hip) ( 30172743) Heel bone mineral density ( 30598549) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30297969) Uterine fibroids ( 30194396 31649266)
Interacting Genes		11 interacting genes: ACTN1 AGTRAP CIDEB DLAT DLD EP300 EWSR1 HSD17B10 OGT PDHB PDK2	11 interacting genes: AKT1 DLAT HIC2 HTT ISOC2 MAP3K8 PDHA1 PDHX PDK1 SGK1 VSIG4
Entrez ID		8050	5164
HPRD ID		02002	03955
Ensembl ID		ENSG00000110435	ENSG00000005882
Uniprot IDs		O00330	Q15119
PDB IDs		1ZY8 2DNC 2F5Z 2F60 6H60	2BTZ 2BU2 2BU5 2BU6 2BU7 2BU8 4MP2 4MP7 4MPC 4MPE 4MPN 4V25 4V26 5J6A 5J71 5M4K 5M4M 5M4N 5M4P 6LIL 6LIN 6LIO 6TMP 6TMQ 6TMZ 6TN0 6TN2
Enriched GO Terms of Interacting Partners?
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