GRPEL1 and DSP

		GRPEL1	DSP
Description		GrpE like 1, mitochondrial	desmoplakin
Image		No pdb structure
GO Annotations	Cellular Component	PAM Complex, Tim23 Associated Import Motor Nucleoplasm Mitochondrion Mitochondrial Matrix	Cornified Envelope Nucleus Cytoplasm Intermediate Filament Plasma Membrane Fascia Adherens Intercalated Disc Membrane Basolateral Plasma Membrane Desmosome Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Unfolded Protein Binding Chaperone Binding	RNA Binding Protein Kinase C Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Scaffold Protein Binding
	Biological Process	Protein Folding Protein Import Into Mitochondrial Matrix Regulation Of Catalytic Activity	Desmosome Organization Ventricular Compact Myocardium Morphogenesis Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Adherens Junction Organization Wound Healing Skin Development Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Epithelial Cell-cell Adhesion Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Protein Localization To Cell-cell Junction
Pathways		Mitochondrial protein import	Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope RND3 GTPase cycle RND1 GTPase cycle
Drugs			Zinc Artenimol Zinc acetate
Diseases
GWAS		Eosinophil percentage of white cells ( 32888494)	Chronic obstructive pulmonary disease ( 28166215 30804561) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Idiopathic pulmonary fibrosis ( 31710517 29066090) Interstitial lung disease ( 23583980) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Numerical cognitive ability ( 31620175) PR interval ( 32439900) Response to fenofibrate (triglyceride levels) ( 27002377) Resting heart rate ( 27798624)
Interacting Genes		13 interacting genes: CCDC57 DSP ERCC6 FAM184B FGFBP2 GALT MED28 NKX3-2 POLR1C SFTPB SPG21 WBP2 XYLB	31 interacting genes: ARID3A CASP10 CASP2 CASP4 CASP6 CASP7 CASP9 CDC42 CDH5 COL17A1 DES DSC1 ENO3 EVPL GRPEL1 IVL JUP KRT1 KRT5 KRT6A MTDH PECAM1 PKP1 PKP2 PKP3 PKP4 PRKACA PRKCE PTEN UCHL5 VIM
Entrez ID		80273	1832
HPRD ID		07550	00513
Ensembl ID		ENSG00000109519	ENSG00000096696
Uniprot IDs		Q9HAV7	B4DKX6 P15924 Q4LE79
PDB IDs			1LM5 1LM7 3R6N 5DZZ
Enriched GO Terms of Interacting Partners?
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