CEP63 and CCDC14

Number of citations of the paper that reports this interaction (PubMedID 26638075)
175

Data Source:
BioGRID (proximity labelling technology, two hybrid, proximity labelling technology)

		CEP63	CCDC14
Description		centrosomal protein 63	coiled-coil domain containing 14
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Centrosome Centriole Cytosol	Cytoplasm Centrosome Centriolar Satellite
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	DNA Damage Checkpoint Signaling Centriole Replication Signal Transduction In Response To DNA Damage Spindle Assembly Cell Division De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation	Substantia Nigra Development Protein Localization To Centrosome
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Height ( 18391952) Hip circumference adjusted for BMI ( 34021172) Late-onset Alzheimer's disease ( 27770636) Neurocognitive impairment in HIV-1 infection (dichotomous) ( 28447399) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Intelligence (MTAG) ( 29326435)
Interacting Genes		67 interacting genes: ALOX5 ARFIP2 ARNT2 BFSP2 BRPF1 CAMKK2 CAPN7 CCDC14 CCDC187 CCHCR1 CCNI CDK1 CEP57 CEP57L1 CWF19L2 DAXX DISC1 DST DTNB DZIP3 EXOC4 EZH2 FAM161A FBF1 FEM1C GSE1 HAUS1 HGS INTS6L KANK2 KXD1 MACF1 MBIP MNS1 NCOR2 NDC80 NDEL1 NXT2 PCNX4 PIBF1 POLR3C PPP1R13B PPP4R1 RCOR3 ROGDI SMARCE1 SMC3 SNRNP70 SPTAN1 SPTBN1 SSX3 STAG1 SYNE1 SYT17 TBC1D15 TBC1D22B TSG101 TSGA10IP TSHZ3 TXLNA TXLNB USHBP1 USP2 ZCCHC10 ZNF148 ZNF250 ZNF774	16 interacting genes: APP CALM1 CEP63 CSNK1D DDX6 KDM1A MAGEA11 MAGEB4 MAPK14 PEX5 PIK3R3 PLAC9 PNKP RNF8 TXLNB UBQLN4
Entrez ID		80254	64770
HPRD ID		07826	07801
Ensembl ID		ENSG00000182923	ENSG00000175455
Uniprot IDs		Q96MT8	Q49A88
PDB IDs		6CSU 6CSV
Enriched GO Terms of Interacting Partners?
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