WLS and SMO

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		WLS	SMO
Description		Wnt ligand secretion mediator	smoothened, frizzled class receptor
Image
GO Annotations	Cellular Component	Golgi Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Endocytic Vesicle Membrane Integral Component Of Organelle Membrane Cytoplasmic Vesicle Early Endosome Membrane Dendrite Membrane Dendrite Cytoplasm Extracellular Exosome	Golgi Apparatus Plasma Membrane Caveola Cilium Integral Component Of Membrane Dendrite Endocytic Vesicle Membrane Intracellular Membrane-bounded Organelle Ciliary Membrane Extracellular Exosome Ciliary Tip 9+0 Non-motile Cilium
	Molecular Function	Protein Binding Wnt-protein Binding Mu-type Opioid Receptor Binding	G Protein-coupled Receptor Activity Patched Binding Protein Binding
	Biological Process	Mesoderm Formation Intracellular Protein Transport Anterior/posterior Axis Specification Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Midbrain Development Hindbrain Development Exocrine Pancreas Development Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Wnt Protein Secretion Positive Regulation Of Wnt Protein Secretion Positive Regulation Of Canonical Wnt Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Neural Crest Cell Migration Heart Looping Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Determination Of Left/right Asymmetry In Lateral Mesoderm Type B Pancreatic Cell Development G Protein-coupled Receptor Signaling Pathway Smoothened Signaling Pathway Positive Regulation Of Hh Target Transcription Factor Activity Ventral Midline Determination Central Nervous System Development Midgut Development Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Dentate Gyrus Development Cerebellar Cortex Morphogenesis Thalamus Development Dorsal/ventral Neural Tube Patterning Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Central Nervous System Neuron Differentiation Cerebral Cortex Development Positive Regulation Of Cell Migration Negative Regulation Of Epithelial Cell Differentiation Hair Follicle Morphogenesis Protein Localization To Nucleus Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Astrocyte Activation Skeletal Muscle Fiber Development Smooth Muscle Tissue Development Forebrain Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Epithelial Cell Proliferation Protein Stabilization Myoblast Migration Negative Regulation Of Hair Follicle Development Contact Inhibition Atrial Septum Morphogenesis Mammary Gland Epithelial Cell Differentiation Epithelial-mesenchymal Cell Signaling Somite Development Pancreas Morphogenesis Left/right Axis Specification Cellular Response To Cholesterol Commissural Neuron Axon Guidance Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Stem Cell Population Maintenance Regulation Of Heart Morphogenesis
Pathways		WNT ligand biogenesis and trafficking	Class B/2 (Secretin family receptors) Hedgehog 'off' state BBSome-mediated cargo-targeting to cilium Hedgehog 'on' state Activation of SMO Activation of SMO
Drugs			Fluocinonide Halcinonide Vismodegib Sonidegib Glasdegib
Diseases
GWAS		Bone mineral density (spine) ( 26911590) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Femoral neck bone mineral density ( 29499414 32239398) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 29499414 22504420) Perceived intensity of sucrose ( 31005972) Postoperative complication after cardiac surgery ( 30678657) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Osteoarthritis (hip) ( 30374069)
Interacting Genes		6 interacting genes: CCR2 DRD2 GPR37 HRH1 OPRM1 SMO	28 interacting genes: ARV1 C18orf32 C4orf3 EMC10 FKBP8 GABARAPL2 GABBR1 HMGN4 HMOX1 HMOX2 ITGB1BP1 JPH3 LEPROT NDFIP1 NEDD4 NGEF NIPA1 PLPP7 PTCH1 PTCH2 RPN2 S1PR5 SLC41A3 SSPN TIMMDC1 TMCC2 TSPAN7 WLS
Entrez ID		79971	6608
HPRD ID		10980	03294
Ensembl ID		ENSG00000116729	ENSG00000128602
Uniprot IDs		Q5T9L3	Q99835
PDB IDs		7KC4	4JKV 4N4W 4O9R 4QIM 4QIN 5L7D 5L7I 5V56 5V57 6OT0 6XBJ 6XBK 6XBL 6XBM
Enriched GO Terms of Interacting Partners?
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