MICALL2 and ACTN4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MICALL2	ACTN4
Description		MICAL like 2	actinin alpha 4
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytosol Plasma Membrane Cell-cell Junction Bicellular Tight Junction Actin Filament Bundle Neuron Projection Recycling Endosome	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Nuclear Body Z Disc Cell Junction Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Protein-containing Complex Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Protein Binding Filamin Binding Small GTPase Binding Actinin Binding Metal Ion Binding Actin Filament Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleoside Binding Transcription Coactivator Activity RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Nuclear Receptor Binding Nuclear Receptor Coactivator Activity Chromatin DNA Binding Protein Homodimerization Activity Retinoic Acid Receptor Binding Transmembrane Transporter Binding Actin Filament Binding
	Biological Process	Actin Filament Polymerization Neuron Projection Development Actin Cytoskeleton Reorganization Endocytic Recycling Substrate Adhesion-dependent Cell Spreading Bicellular Tight Junction Assembly Positive Regulation Of Protein Targeting To Mitochondrion	Protein Transport Actin Cytoskeleton Organization Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Positive Regulation Of Sodium:proton Antiporter Activity Tumor Necrosis Factor-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Cellular Component Movement Muscle Cell Development Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Nucleic Acid-templated Transcription
Pathways			Platelet degranulation Nephrin family interactions
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 29403010) Creatinine levels ( 29403010) Executive inhibition (Stroop WIT and CIT) in attention deficit hyperactivity disorder ( 28416812) Glomerular filtration rate ( 29403010) Hematocrit ( 29403010) Hemoglobin ( 29403010) Red blood cell count ( 29403010) Resistance to antihypertensive treatment in hypertension ( 31545351) Restless legs syndrome ( 33239738) Serum uric acid levels ( 30993211 29403010) Zinc levels ( 26025379)	Brain morphology (MOSTest) ( 32665545) Fasting glucose ( 34074324) Heart rate ( 23583979) Immature fraction of reticulocytes ( 32888494) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Mean platelet volume ( 32888494) Retinal venular tortuosity ( 31597446) Waist circumference ( 28552196)
Interacting Genes		6 interacting genes: ACTN1 ACTN2 ACTN3 ACTN4 CDR2 DCDC2	55 interacting genes: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 C14orf119 CAMK2A CAMK2B CAMK2G CDKN2A COIL COL17A1 DDIAS ESR1 GSN HDAC7 HSPB1 INO80 ITGB1 KPNA2 LCMT2 LNX1 LRRC7 MAGI1 MAPK7 MEF2A MEOX2 MICALL2 MYOZ1 MYOZ2 NEB NOS2 NOS3 PDLIM1 POT1 PTGER4 PTPN11 PTPN6 RARA RPS27 SACS SERPINE1 SLC2A4 SLC9A3R2 SORBS2 STAT1 TJP1 TRIM23 TRIM3 TTN TXN UCHL5 USP6NL VDR
Entrez ID		79778	81
HPRD ID		11364	05222
Ensembl ID		ENSG00000164877	ENSG00000130402
Uniprot IDs		Q6UWK3 Q8IY33	A0A0S2Z3G9 F5GXS2 H7C144 O43707
PDB IDs			1WLX 1YDI 2R0O 6O31 6OA6
Enriched GO Terms of Interacting Partners?
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