MAFK and NFE2L3

Number of citations of the paper that reports this interaction (PubMedID 10037736)
92

Data Source:
HPRD (two hybrid, in vitro)

		MAFK	NFE2L3
Description		MAF bZIP transcription factor K	nuclear factor, erythroid 2 like 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding RING-like Zinc Finger Domain Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Nervous System Development	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II
Pathways		Regulation of HMOX1 expression and activity Heme signaling Regulation of BACH1 activity Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549 33730874) Apolipoprotein B levels ( 32203549) Body mass index ( 23583978) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Endometriosis ( 28333195) Gamma glutamyl transferase levels ( 29403010 33339817) Height ( 31562340) LDL cholesterol levels ( 32203549 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 29403010 33339817) Obesity-related traits ( 23251661) Phoneme awareness ( 30741946) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Superior frontal gyrus grey matter volume ( 25335168) Total cholesterol levels ( 29403010 33339817) Triglyceride levels ( 32203549 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		11 interacting genes: BACH1 BACH2 DNMT3L HIF1A HOXD12 KAT6A MARS1 NFE2 NFE2L1 NFE2L2 NFE2L3	8 interacting genes: BACH2 CREB3 GSK3B MAFK NFE2 NFE2L1 NFE2L2 PPARG
Entrez ID		7975	9603
HPRD ID		02561	09162
Ensembl ID		ENSG00000198517	ENSG00000050344
Uniprot IDs		A0A024R804 O60675	Q9Y4A8
PDB IDs
Enriched GO Terms of Interacting Partners?
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