SUV39H2 and SNF8

Number of citations of the paper that reports this interaction (PubMedID 23455924)
46

Data Source:
BioGRID (two hybrid)

		SUV39H2	SNF8
Description		SUV39H2 histone lysine methyltransferase	SNF8 subunit of ESCRT-II
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm	ESCRT II Complex Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Plasma Membrane Endosome Membrane Membrane Late Endosome Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding Protein Binding Zinc Ion Binding Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) S-adenosyl-L-methionine Binding	Protein Binding Protein C-terminus Binding Channel Regulator Activity Protein Homodimerization Activity Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Assembly Or Disassembly Chromatin Remodeling Cell Cycle Cell Differentiation Histone Lysine Methylation Histone H3-K9 Dimethylation Histone H3-K9 Trimethylation Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Rhythmic Process Cellular Response To Hypoxia	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Macroautophagy Endocytic Recycling Multivesicular Body Assembly Regulation Of Protein Catabolic Process Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of MAP Kinase Activity Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Regulation Of Protein Complex Stability Multivesicular Body Sorting Pathway Positive Regulation Of Exosomal Secretion Regulation Of Viral Budding Via Host ESCRT Complex
Pathways		PKMTs methylate histone lysines	Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events
Drugs
Diseases
GWAS		Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)	Coronary heart disease ( 21378990) Hip circumference adjusted for BMI ( 34021172) Type 2 diabetes ( 29358691)
Interacting Genes		41 interacting genes: AKAP9 APPL2 AR BLZF1 C8orf74 CBX7 CDCA4 CEP70 CFAP100 CGGBP1 EWSR1 FAM20C GOLGA6L9 GSTCD ID2 KCTD17 KLF3 KLHDC4 LCA5L LNX1 LRIF1 MAGEA11 MCM3AP MRFAP1 MTF2 MYL12A NME4 ODAD3 PHF19 PNMA1 POLR3F RAB3IP RASSF1 SHC1 SMAD5 SNF8 UBE2V2 WIZ ZNF212 ZNF557 ZNF57	25 interacting genes: ADORA1 AKAP9 CHMP6 CLP1 CT55 DVL2 ELL FANCL GLYCTK GOLGA2 HMOX1 KDM1A NIF3L1 PRMT6 RILP SMARCD1 SUOX SUV39H2 TRIM54 TSG101 TXLNA VAC14 VPS25 VPS36 YWHAE
Entrez ID		79723	11267
HPRD ID		07580	16847
Ensembl ID		ENSG00000152455	ENSG00000159210
Uniprot IDs		Q9H5I1	Q96H20
PDB IDs		2R3A 6P0R	2ZME 3CUQ
Enriched GO Terms of Interacting Partners?
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