SMC6 and SLF2

Number of citations of the paper that reports this interaction (PubMedID 32389690)
5

Data Source:
BioGRID (pull down, pull down)

		SMC6	SLF2
Description		structural maintenance of chromosomes 6	SMC5-SMC6 complex localization factor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromosome, Telomeric Region Sex Chromosome Nucleus Nucleoplasm PML Body Nuclear Speck Smc5-Smc6 Complex Interchromatin Granule Site Of Double-strand Break Mitotic Spindle Pole	Chromatin Nucleus Nucleoplasm Site Of Double-strand Break Intracellular Membrane-bounded Organelle
	Molecular Function	Damaged DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Ubiquitin Protein Ligase Binding	Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination Cellular Response To DNA Damage Stimulus Positive Regulation Of Chromosome Segregation Cellular Senescence	DNA Repair Cellular Response To DNA Damage Stimulus Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Protein Localization To Site Of Double-strand Break Positive Regulation Of Double-strand Break Repair
Pathways		SUMOylation of DNA damage response and repair proteins
Drugs
Diseases
GWAS		LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Total cholesterol levels ( 30275531)	Age at first birth ( 34211149) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung cancer ( 28604730)
Interacting Genes		1 interacting genes: SLF2	8 interacting genes: CALM1 OPTN PSMA1 SFMBT2 SLF1 SMC5 SMC6 TRIM14
Entrez ID		79677	55719
HPRD ID		10242	12581
Ensembl ID		ENSG00000163029	ENSG00000119906
Uniprot IDs		A0A2S1ZR87 Q96SB8	Q8IX21
PDB IDs
Enriched GO Terms of Interacting Partners?
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