NLRX1 and SARM1

Number of citations of the paper that reports this interaction (PubMedID 21903422)
143

Data Source:
BioGRID (affinity chromatography technology, pull down)

		NLRX1	SARM1
Description		NLR family member X1	sterile alpha and TIR motif containing 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Plasma Membrane Cell Junction	Cytoplasm Mitochondrion Cytosol Microtubule Axon Dendrite Extrinsic Component Of Mitochondrial Outer Membrane Synapse
	Molecular Function	Protein Binding ATP Binding	NAD+ Nucleosidase Activity Protein Binding Signaling Adaptor Activity NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Intracellular Signal Transduction Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Inflammatory Response	Signal Transduction Nervous System Development Response To Glucose NAD Catabolic Process Cell Differentiation Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Innate Immune Response Response To Axon Injury Regulation Of Dendrite Morphogenesis Regulation Of Neuron Death Positive Regulation Of Neuron Death
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494)	Amyotrophic lateral sclerosis ( 27455348) Amyotrophic lateral sclerosis (sporadic) ( 28931804) Blood protein levels ( 29875488 28240269) Osteoprotegerin levels ( 25080503)
Interacting Genes		9 interacting genes: ABCG4 BUD13 C1QTNF5 IFT46 PDZD3 SARM1 SCN3B TMEM25 TMPRSS4	6 interacting genes: CCDC47 IRAK2 MYD88 NLRX1 STT3A TICAM2
Entrez ID		79671	23098
HPRD ID		17640	09664
Ensembl ID		ENSG00000160703	ENSG00000004139
Uniprot IDs		Q86UT6	Q05B42 Q0D2N8 Q6SZW1
PDB IDs		3UN9	6O0Q 6O0R 6O0S 6O0T 6O0U 6O0V 6O1B 6QWV 6WPK 6ZFX 6ZG0 6ZG1 7ANW 7CM5 7CM6 7CM7
Enriched GO Terms of Interacting Partners?
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