CALCA and NRDC

Number of citations of the paper that reports this interaction (PubMedID 12590613)
4

Data Source:
HPRD (in vitro)

		CALCA	NRDC
Description		calcitonin related polypeptide alpha	nardilysin convertase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Neuronal Cell Body Terminal Bouton	Mitochondrion Cytosol Cell Surface
	Molecular Function	Hormone Activity Protein Binding Calcitonin Receptor Binding Identical Protein Binding	Metalloendopeptidase Activity Protein Binding Metal Ion Binding Epidermal Growth Factor Binding
	Biological Process	Artery Vasodilation Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Monocyte Chemotaxis Inflammatory Response Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Embryo Implantation Aging Feeding Behavior Regulation Of Heart Contraction Response To Heat Negative Regulation Of Ossification Activation Of Protein Kinase Activity Negative Regulation Of Bone Resorption Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Smooth Muscle Contraction Response To Pain Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Cellular Response To Tumor Necrosis Factor Cellular Response To Nerve Growth Factor Stimulus	Proteolysis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Endopeptidase Activity Negative Regulation Of Cold-induced Thermogenesis
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production Amyloid fiber formation G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs		Olcegepant Telcagepant Eptinezumab Fremanezumab Galcanezumab
Diseases
GWAS		Diverticular disease ( 30177863) Hip circumference adjusted for BMI ( 34021172) Vitamin D levels ( 25208829)
Interacting Genes		8 interacting genes: ANKRD11 BBS1 BBS4 CALCRL ECE1 NRDC RAMP1 RAMP2	11 interacting genes: CALCA FGF11 H3C14 HBEGF IRS1 NLGN3 PDYN POMC RPS26P15 TTC39A ZFYVE9
Entrez ID		796	4898
HPRD ID		00238	04036
Ensembl ID		ENSG00000110680	ENSG00000078618
Uniprot IDs		P01258 P06881	G3V1R5 O43847 Q6UUU9
PDB IDs		1LS7 2JXZ 6E3Y 7KNU
Enriched GO Terms of Interacting Partners?
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