MUL1 and UBE2D4

Number of citations of the paper that reports this interaction (PubMedID 28763789)
36

Data Source:
BioGRID (pull down)

		MUL1	UBE2D4
Description		mitochondrial E3 ubiquitin protein ligase 1	ubiquitin conjugating enzyme E2 D4 (putative)
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Peroxisome Membrane Axon Integral Component Of Mitochondrial Outer Membrane Neuronal Cell Body	Ubiquitin Ligase Complex Nucleus
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Mitochondrial Fission Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Protein Ubiquitination Protein Sumoylation Negative Regulation Of Cell Growth Protein Destabilization Positive Regulation Of Protein Sumoylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus By Host Protein Stabilization Mitochondrion Localization Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Dendrite Extension Positive Regulation Of Autophagy Of Mitochondrion In Response To Mitochondrial Depolarization	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination
Pathways		Ub-specific processing proteases	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Proportion of activated microglia (inferior temporal cortex) ( 30679421)
Interacting Genes		34 interacting genes: AKT1 APPBP2 CDC34 DNM1L EHD1 HTRA2 KRTAP10-8 MAP3K7 RANGAP1 REEP2 STING1 SUMO1 TAP1 TP53 TP73 TRIM9 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2U UBE2V2 UBE2W UBXN7 ULK1	107 interacting genes: AMFR ARIH2 BFAR BIRC8 CADPS2 CHFR CNOT4 DAZAP2 DTX1 DTX2 DTX3 DTX3L DZIP3 IKBKG INCA1 ITCH LNX1 LRSAM1 MAGEA11 MAP3K1 MARCHF3 MDM2 MGRN1 MIB1 MID1 MID2 MKRN1 MKRN2 MKRN3 MUL1 MYBL2 MYLIP OTUB1 PHF7 PJA2 POLR2E PRKN RBCK1 RCHY1 REL RFWD3 RING1 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF13 RNF130 RNF138 RNF14 RNF150 RNF165 RNF166 RNF167 RNF181 RNF185 RNF2 RNF216 RNF26 RNF31 RNF38 RNF4 RNF43 RNF5 RNF7 SIAH1 STUB1 TOPORS TRAF6 TRAF7 TRIM10 TRIM17 TRIM2 TRIM23 TRIM25 TRIM27 TRIM3 TRIM31 TRIM35 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM62 TRIM8 UBA1 UBC UBE4A UBOX5 UBTD1 UBTD2 UFM1 UHRF2 UVSSA XIAP ZNRF1 ZNRF2 ZNRF4
Entrez ID		79594	51619
HPRD ID		07799	14242
Ensembl ID		ENSG00000090432	ENSG00000078967
Uniprot IDs		A1PUM0 Q969V5	A0A024RA90 Q9UQL0 Q9Y2X8
PDB IDs		6K2K
Enriched GO Terms of Interacting Partners?
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