CDC73 and GC

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CDC73	GC
Description		cell division cycle 73	GC vitamin D binding protein
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Cdc73/Paf1 Complex	Extracellular Region Extracellular Space Cytoplasm Cytosol Lysosomal Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	RNA Polymerase II Complex Binding Protein Binding	Actin Binding Vitamin D Binding Vitamin Transmembrane Transporter Activity Calcidiol Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Endodermal Cell Fate Commitment Transcription Elongation From RNA Polymerase II Promoter MRNA Polyadenylation Cell Cycle Negative Regulation Of Cell Population Proliferation Histone Monoubiquitination Wnt Signaling Pathway Stem Cell Population Maintenance Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of MRNA 3'-end Processing Protein Destabilization Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Recruitment Of 3'-end Processing Factors To RNA Polymerase II Holoenzyme Complex Negative Regulation Of Apoptotic Process Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Transport Vitamin Transmembrane Transport Vitamin D Metabolic Process Vitamin Transport
Pathways		Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins	Vitamin D (calciferol) metabolism
Drugs			Vitamin D
Diseases
GWAS		Chronotype ( 30696823) High density lipoprotein cholesterol levels ( 34074324) Ovarian disease with few adhesions ( 28333195) Photic sneeze reflex ( 27182965) Subcutaneous adipose tissue ( 22589738) Takayasu arteritis ( 25604533) White matter hyperintensity burden ( 25663218)	Blood protein levels ( 29875488) Granulocyte count ( 27863252) Lymphocyte counts ( 32888494) Metabolite levels ( 22916037) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neonatal total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Neutrophil count ( 32888494 27863252) Non-alcoholic fatty liver disease histology (other) ( 23213074) Platelet count ( 32888494) Plateletcrit ( 32888494) Refractive error ( 32231278) Serum 25-Hydroxyvitamin D levels ( 33382404 29545823 29325163 31841498) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum vitamin D-binding protein levels ( 24740207) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Vitamin D insufficiency ( 20541252) Vitamin D levels ( 29343764 22673963 20418485 25208829) Vitamin D levels (dietary vitamin D intake interaction) ( 29343764) White blood cell count ( 32888494 27863252)
Interacting Genes		35 interacting genes: ALAS1 ANXA6 CEP70 CTNNB1 DDAH2 FAF1 FSD2 GC GOLGA2 GOLGA6L9 H1-2 HAP1 HSF2BP HSPA4 ITFG1 KASH5 KCNH2 KIAA1549 KIDINS220 MCM3AP MTUS2 MYC PICK1 PITHD1 RABEP1 RNF20 RNF40 TCEA1 TCF4 TFCP2 TOMM20 TRIM23 TSGA10 VPS37B WWC1	14 interacting genes: ACTA1 ACTA2 ACTC1 C3 CCND3 CDC73 CUBN GRB2 HSP90AA1 LRIF1 LRP2 PIK3R3 SERF2 SLC9A3R1
Entrez ID		79577	2638
HPRD ID		09581	00749
Ensembl ID		ENSG00000134371	ENSG00000145321
Uniprot IDs		Q6P1J9	P02774
PDB IDs		5YDE 5YDF 6TED	1J78 1J7E 1KW2 1KXP 1LOT 1MA9
Enriched GO Terms of Interacting Partners?
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