WDR77 and SUZ12

Number of citations of the paper that reports this interaction (PubMedID 22169276)
35

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology)

		WDR77	SUZ12
Description		WD repeat domain 77	SUZ12 polycomb repressive complex 2 subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Methylosome Pole Plasm	Nucleus Nucleoplasm Nucleolus Nuclear Body ESC/E(Z) Complex
	Molecular Function	Protein Binding Methyl-CpG Binding Nuclear Receptor Coactivator Activity	Transcription Corepressor Binding Protein Binding Enzyme Activator Activity Chromatin DNA Binding Methylated Histone Binding Histone Methyltransferase Activity Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Pole Plasm Assembly Positive Regulation Of Cell Population Proliferation Positive Regulation Of Transcription, DNA-templated Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development	Spinal Cord Development Response To Retinoic Acid Negative Regulation Of Chemokine Production Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Cell Differentiation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Catalytic Activity Histone H3-K27 Trimethylation
Pathways		snRNP Assembly RMTs methylate histone arginines	PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines SUMOylation of chromatin organization proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis
Drugs
Diseases
GWAS			High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 25673412)
Interacting Genes		47 interacting genes: AQR BAG2 CDK19 CDK8 CLNS1A CREBBP CTDP1 EIF4A1 GLI1 GPKOW H2AC21 HNRNPM LSM3 NKX3-1 PCBP2 PDCD4 PITRM1 PPIL1 PPP1R8 PQBP1 PRKG1 PRKG2 PRMT5 QKI RBM5 RIOK1 SAP30BP SF1 SF3A1 SF3B4 SIRT7 SMAD1 SMYD1 SNRPB SNRPC SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SUZ12 THOC1 TOE1 YWHAB YWHAQ ZMYND19 ZNF207	25 interacting genes: AEBP2 ARHGAP5 BCL11A CDK19 CDK5R1 CDK8 CREB1 EZH2 H1-1 H3-4 KLRC1 LATS2 MED17 MED6 NOL4 NR1D1 PAXIP1 PJA1 PLA2G2A PRDM14 RBBP4 SLC2A2 TBC1D29P UBE2I WDR77
Entrez ID		79084	23512
HPRD ID		14387	06949
Ensembl ID		ENSG00000116455	ENSG00000178691
Uniprot IDs		A0A024R0H7 Q9BQA1	J3QQW9 Q15022
PDB IDs		4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S 6RLL 6RLQ 6UGH 6UXX 6UXY 6V0N 6V0O 6V0P	4W2R 5HYN 5IJ7 5IJ8 5LS6 5WAI 5WAK 5WG6 6B3W 6C23 6C24 6NQ3 6WKR 7AT8 7KSO 7KSR 7KTP
Enriched GO Terms of Interacting Partners?
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