MAPKAPK3 and SMS

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		MAPKAPK3	SMS
Description		MAPK activated protein kinase 3	spermine synthase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytosol Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity	Spermine Synthase Activity
	Biological Process	MAPK Cascade Toll-like Receptor Signaling Pathway Signal Transduction Peptidyl-serine Phosphorylation Response To Lipopolysaccharide Response To Cytokine Intracellular Signal Transduction Macropinocytosis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway	Methionine Metabolic Process Polyamine Metabolic Process Spermine Biosynthetic Process
Pathways		p38MAPK events Oxidative Stress Induced Senescence VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation	Metabolism of polyamines
Drugs		2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE	Spermine
Diseases
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cortical surface area (MOSTest) ( 32665545) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) High light scatter reticulocyte count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		22 interacting genes: APP ATF1 BECN1 CHMP2A COPS6 EEF2 EEF2K EZH2 HSPB1 IGHM LINC02582 MAPK13 MAPK14 NEDD4 NEDD4L RAB2A RCSD1 SMS SRPK2 SUMO3 TCF3 THAP12	6 interacting genes: EZH2 LARP7 MAPK6 MAPK8IP2 MAPKAPK3 RPS6KA3
Entrez ID		7867	6611
HPRD ID		03678	02115
Ensembl ID		ENSG00000114738	ENSG00000102172
Uniprot IDs		A0A024R2W7 Q16644	P52788
PDB IDs		3FHR 3FXW 3R1N 3SHE	3C6K 3C6M
Enriched GO Terms of Interacting Partners?
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