CACNG1 and GAD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CACNG1	GAD2
Description		calcium voltage-gated channel auxiliary subunit gamma 1	glutamate decarboxylase 2
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane T-tubule Sarcolemma L-type Voltage-gated Calcium Channel Complex	Golgi Membrane Cytosol Plasma Membrane Axon Synaptic Vesicle Membrane Anchored Component Of Membrane Presynaptic Membrane Perinuclear Region Of Cytoplasm Inhibitory Synapse Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
	Molecular Function	Voltage-gated Calcium Channel Activity Calcium Channel Regulator Activity Protein Binding	Glutamate Decarboxylase Activity Protein Binding Glutamate Binding Pyridoxal Phosphate Binding Protein-containing Complex Binding
	Biological Process	Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel	Glutamate Decarboxylation To Succinate Chemical Synaptic Transmission Response To Xenobiotic Stimulus Neurotransmitter Biosynthetic Process
Pathways			GABA synthesis GABA synthesis, release, reuptake and degradation MECP2 regulates transcription of genes involved in GABA signaling
Drugs		Ergocalciferol Enflurane Ibutilide Diltiazem Spironolactone Lercanidipine Ethanol Fluspirilene Butamben Bioallethrin	Pyridoxal phosphate Glutamic acid
Diseases
GWAS		Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Fasting glucose ( 34059833) Glycated hemoglobin levels ( 34059833) Lean body mass ( 28552196)
Interacting Genes		13 interacting genes: CPLX4 FFAR2 GAD2 GPX8 HSD17B13 LMNA MGST3 MUC1 ODF4 THAP4 TLCD4 TMEM45B VAPA	48 interacting genes: ABHD5 AGTRAP APOC2 APOC4 ARL13B ARL6IP1 ARMC12 BASP1 BSND CACNG1 CALM1 CMTM5 CPLX4 CYB561D1 DERL1 DERL3 DGAT2L6 DMKN F10 FADS6 FAM114A2 FAM163A GAD1 HIGD1C LDAF1 LIME1 MAL2 MAP3K8 MEST MRM3 PBX3 PLIN3 PRKACA PRKCE RDH10 RHEX RPRM SCAMP1 SDR16C5 SEC22A SMPD2 SPG21 SYCE2 SYNGR3 TMEM120B TMEM128 TNFRSF10D TSPAN33
Entrez ID		786	2572
HPRD ID		00249	11817
Ensembl ID		ENSG00000108878	ENSG00000136750
Uniprot IDs		Q06432	Q05329 Q5VZ30
PDB IDs			1ES0 2OKK
Enriched GO Terms of Interacting Partners?
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