FZD5 and ABI3BP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		FZD5	ABI3BP
Description		frizzled class receptor 5	ABI family member 3 binding protein
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Plasma Membrane Integral Component Of Plasma Membrane Bicellular Tight Junction Cell Surface Integral Component Of Membrane Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane Perikaryon Synapse Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix
	Molecular Function	Amyloid-beta Binding G Protein-coupled Receptor Activity Protein Binding Lipid Binding Wnt-protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity Protein-containing Complex Binding	Extracellular Matrix Structural Constituent
	Biological Process	Embryonic Axis Specification Angiogenesis Positive Regulation Of T Cell Cytokine Production G Protein-coupled Receptor Signaling Pathway Synapse Assembly Negative Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Neuron Differentiation Post-embryonic Camera-type Eye Development Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Embryonic Camera-type Eye Morphogenesis Spemann Organizer Formation Canonical Wnt Signaling Pathway Apoptotic Process Involved In Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Labyrinthine Layer Blood Vessel Development Chorionic Trophoblast Cell Differentiation Cellular Response To Molecule Of Bacterial Origin Regulation Of Chorionic Trophoblast Cell Proliferation Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Bicellular Tight Junction Assembly
Pathways		Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway Asymmetric localization of PCP proteins Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Signaling by RNF43 mutants
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494)	Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Alcohol dependence ( 26365420) Asthma (childhood onset) ( 23829686) Carotid plaque burden ( 28282560) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Joint mobility (Beighton score) ( 27182965) Multiple sclerosis ( 31604244) Optic disc area ( 25631615 28073927) Optic disc size ( 31809533) Post bronchodilator FEV1 in COPD ( 26634245) Refractive error ( 32231278) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		14 interacting genes: ABI3BP CFLAR GOPC GSK3B LRP6 LZTFL1 RGS2 ROR2 RPS6KA6 SLC22A2 SLC35B1 UBTD1 WNT5A WNT7A	6 interacting genes: ABI3 CBX1 FZD5 GOT1 GRB2 MBNL1
Entrez ID		7855	25890
HPRD ID		03427	09380
Ensembl ID		ENSG00000163251	ENSG00000154175
Uniprot IDs		Q13467	Q7Z7G0
PDB IDs		5URY 5URZ 6O39 6WW2
Enriched GO Terms of Interacting Partners?
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