ALMS1 and HRH4

		ALMS1	HRH4
Description		ALMS1 centrosome and basal body associated protein	histamine receptor H4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spindle Pole Centrosome Centriole Cytosol Cilium	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse
	Molecular Function	Molecular_function Microtubule Binding	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity
	Biological Process	Endosomal Transport Regulation Of Centriole Replication Regulation Of Stress Fiber Assembly Positive Regulation Of Cold-induced Thermogenesis	Inflammatory Response G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Biological_process Regulation Of MAPK Cascade G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Histamine receptors G alpha (i) signalling events
Drugs			Amitriptyline Clozapine Loxapine Chlorpromazine Amoxapine Doxepin Aripiprazole Pheniramine REV131 Histamine Mianserin
Diseases
GWAS		Age at voice drop ( 27182965) Blood metabolite levels ( 26401656) Chronic kidney disease ( 20383146) Creatinine levels ( 20383145) Estimated glomerular filtration rate ( 31015462 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) High density lipoprotein cholesterol levels ( 33339817) Intelligence (MTAG) ( 29326435) Menarche (age at onset) ( 27182965) Metabolite levels ( 21931564) Metabolite levels (X-11787) ( 23934736) Retinitis pigmentosa ( 33514863) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 33031748 23093944) Urinary metabolite levels in chronic kidney disease ( 29545352) Urinary metabolite ratios in chronic kidney disease ( 29545352) Urinary metabolites (H-NMR features) ( 24586186)	Adult body size ( 32376654) Chronotype ( 30696823) Diastolic blood pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Lung cancer ( 34062886) Response to taxane treatment (docetaxel) ( 23006423)
Interacting Genes		7 interacting genes: CNOT7 ELN GTF2IRD1 HRH4 LIG4 MEGF10 SLC4A5	6 interacting genes: ALMS1 CCL16 GNA15 GNAI1 GNAO1 SERPINB7
Entrez ID		7840	59340
HPRD ID		06023	06004
Ensembl ID		ENSG00000116127	ENSG00000134489
Uniprot IDs		Q8TCU4	B2KJ49 Q9H3N8
PDB IDs
Enriched GO Terms of Interacting Partners?
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