DAP3 and ESR2

Number of citations of the paper that reports this interaction (PubMedID 29509190)
9

Data Source:
BioGRID (affinity chromatography technology, pull down)

		DAP3	ESR2
Description		death associated protein 3	estrogen receptor 2
Image
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Small Ribosomal Subunit	Chromatin Nucleus Nucleoplasm Mitochondrion
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding GTP Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Steroid Hormone Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Enzyme Binding Estrogen Receptor Activity Estrogen Response Element Binding Receptor Antagonist Activity
	Biological Process	Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Growth Intracellular Steroid Hormone Receptor Signaling Pathway Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of DNA-binding Transcription Factor Activity Cellular Response To Estradiol Stimulus Negative Regulation Of Signaling Receptor Activity
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Nuclear Receptor transcription pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ESR-mediated signaling Extra-nuclear estrogen signaling
Drugs			Diethylstilbestrol Conjugated estrogens Progesterone Raloxifene Estrone Tamoxifen Estradiol Trilostane Estramustine Oxybenzone Genistein Prasterone Benzophenone Phthalic Acid Pyrazole Para-Mercury-Benzenesulfonic Acid Naringenin ICI-164384 5-Alpha-Androstane-3-Beta,17beta-Diol 4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)Phenol Quercetin Afimoxifene Estriol Estrone sulfate MF101 CHF 4227 TAS-108 Lasofoxifene Arzoxifene Bazedoxifene Prinaberel ERB-196 [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE 4-(6-HYDROXY-BENZO[D]ISOXAZOL-3-YL)BENZENE-1,3-DIOL 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL (3aS,4R,9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL 17alpha-Estriol (9aS)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one Erteberel (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL Eugenol Octocrylene Enzacamene Equol 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenol Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate Estriol tripropionate Fluoroestradiol F-18
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Atrial fibrillation ( 30061737) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 29700475) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Metabolite levels ( 23823483) Prostate cancer ( 26443449) Red blood cell count ( 32888494 27863252)
Interacting Genes		14 interacting genes: AHR AR ESR1 ESR2 FADD HIF1A HSP90AA1 NR3C1 PGR PPARA PTEN THRA TNFRSF10A TNFRSF25	106 interacting genes: AGR3 AKAP13 AKT1 ARID5A BCAS2 CALM1 CALM2 CALM3 CASC3 CASZ1 CCNC CDK8 CYSRT1 DAP3 DDX54 DKK3 DNMT3L DNTTIP2 EP300 ESR1 HOXA1 IL13RA2 IL24 ITIH5 JMJD1C KAT5 KLK9 KPNA3 KPRP KRTAP6-2 LCK LRATD2 MAD2L1 MAPK1 MAPK11 MED1 MED10 MED12 MED14 MED16 MED17 MED20 MED21 MED23 MED24 MED6 MED7 MEOX2 MKNK2 MMS19 MRC2 MSH2 NCOA1 NCOA2 NCOA3 NCOA6 NCOA7 NCOR1 NCOR2 NFKBIB NFKBID NOTCH2NLA NR0B1 NR0B2 NRIP1 OXT PELP1 PIAS1 PIAS2 PIAS3 PLSCR1 PNRC1 PNRC2 PPARGC1A PPP5C PRMT2 PRSS50 PSMC3IP PSMC5 RBFOX2 RBM39 REXO4 RFX6 SERPINH1 SGPP1 SMAD2 SMAD3 SMAD4 SMARCE1 SP1 SRA1 SRC SREBF1 STAT5A SYNE2 TFF1 TRAM1 TRIM24 TRIM59 TRIP4 TXNRD1 WIPI1 YWHAH YWHAQ ZBTB17 ZNHIT3
Entrez ID		7818	2100
HPRD ID		03646	03390
Ensembl ID		ENSG00000132676	ENSG00000140009
Uniprot IDs		P51398	A0A348FV93 F1D8N3 Q0PTK2 Q7LCB3 Q92731
PDB IDs		3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5I 7A5K	1L2J 1NDE 1QKM 1U3Q 1U3R 1U3S 1U9E 1X76 1X78 1X7B 1X7J 1YY4 1YYE 1ZAF 2FSZ 2GIU 2I0G 2JJ3 2NV7 2QTU 2YJD 2YLY 2Z4B 3OLL 3OLS 3OMO 3OMP 3OMQ 4J24 4J26 4ZI1 5TOA
Enriched GO Terms of Interacting Partners?
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