ZYX and CASS4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ZYX	CASS4
Description		zyxin	Cas scaffold protein family member 4
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Cytosol Plasma Membrane Adherens Junction Focal Adhesion Actin Cytoskeleton Phagocytic Vesicle	Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion
	Molecular Function	RNA Binding Protein Binding Metal Ion Binding	Protein Tyrosine Kinase Binding
	Biological Process	Cell-matrix Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Stress Fiber Assembly Regulation Of Inflammatory Response Cellular Response To Interferon-gamma	Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Tyrosine Kinase Activity Actin Filament Reorganization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways
Drugs		Artenimol
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 28240269) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) White blood cell count (basophil) ( 27863252)	Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Cognitive decline (age-related) ( 28078323) Family history of Alzheimer's disease ( 30617256) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Refractive astigmatism ( 25367360)
Interacting Genes		35 interacting genes: ACTN1 ATXN1 BSPRY CASS4 ENAH EVL HIPK3 IMP3 LAP3 LASP1 LATS1 LIN7A NEBL NEDD9 NME5 OPRM1 PDLIM5 PHF21A QRICH1 RABEPK RGS2 RPH3AL RTN4IP1 SIAH1 SREBF2 TES TUFT1 VASP VAV1 VAV3 WNK1 YPEL3 ZHX1 ZNF384 ZNF512B	6 interacting genes: ANKS1B CDC42EP2 FHL3 HSF2BP RAE1 ZYX
Entrez ID		7791	57091
HPRD ID		03592	09842
Ensembl ID		ENSG00000159840	ENSG00000087589
Uniprot IDs		Q15942 Q96AF9	B4DII4 Q9NQ75
PDB IDs			2CRE
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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