TRIM25 and PLAAT4

Number of citations of the paper that reports this interaction (PubMedID 18948594)
120

Data Source:
BioGRID (pull down)

		TRIM25	PLAAT4
Description		tripartite motif containing 25	phospholipase A and acyltransferase 4
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Cytoplasmic Stress Granule Nuclear Body	Cytoplasm Cytosol Membrane Integral Component Of Membrane
	Molecular Function	Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity RIG-I Binding Cadherin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Phospholipase A2 Activity Protein Binding Phospholipase A1 Activity N-acyltransferase Activity Acyltransferase Activity Phosphatidylserine 1-acylhydrolase Activity 1-acyl-2-lysophosphatidylserine Acylhydrolase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Ubiquitin-dependent ERAD Pathway Regulation Of Protein Localization Response To Vitamin D RIG-I Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Estrogen Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Release From Host Cell Cellular Response To Leukemia Inhibitory Factor	Phospholipid Metabolic Process Negative Regulation Of Cell Population Proliferation Lipid Catabolic Process Phosphatidylethanolamine Acyl-chain Remodeling Positive Regulation Of Keratinocyte Differentiation N-acylphosphatidylethanolamine Metabolic Process Positive Regulation Of Protein-glutamine Gamma-glutamyltransferase Activity
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Ovarian tumor domain proteases Interferon gamma signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling	Acyl chain remodelling of PE
Drugs
Diseases
GWAS		Height ( 18391951) Lean body mass ( 28552196)
Interacting Genes		58 interacting genes: AMFR APC DDX58 DICER1 ERCC2 ERG ESR1 GATA1 GRIK2 MAP3K13 MEIS2 MIR1-1 MIR155 MIR16-2 MIR19B2 MIR205 MIR206 MIR21 MIR221 MIR25 MIR29A MIR29B1 MIR34A MIR363 MIR7-1 MIR92A1 MIR92A2 MIR98 MIRLET7A1 MIRLET7A3 MTA1 OTUB2 PAX2 PITX2 PLAAT4 RBCK1 RNF31 SFN SLC26A4-AS1 STK11 STK38 SUMO2 TFG TRAF6 TRIM8 UBC UBE2D1 UBE2D2 UBE2D4 UBE2J2 UBE2L3 UBE2L6 UBE2N UBE2V1 USP15 USP39 YWHAQ ZNF24	7 interacting genes: HRAS KMT2A PIK3R3 SGTA TGM1 TRIM25 UBE2I
Entrez ID		7706	5920
HPRD ID		02711	05479
Ensembl ID		ENSG00000121060	ENSG00000133321
Uniprot IDs		Q14258	Q9UL19
PDB IDs		4CFG 4LTB 5EYA 5FER 5NT1 5NT2 6FLM 6FLN	2LKT 2MY9
Enriched GO Terms of Interacting Partners?
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